| Literature DB >> 27414255 |
Homan Kang1, Julien Gravier1,2,3, Kai Bao1, Hideyuki Wada1, Jeong Heon Lee1, Yoonji Baek1, Georges El Fakhri1, Sylvain Gioux1, Brian P Rubin4, Jean-Luc Coll5,6, Hak Soo Choi7.
Abstract
Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.Entities:
Keywords: drug delivery; nanoparticles; optical imaging; renal clearance; theranostics
Mesh:
Substances:
Year: 2016 PMID: 27414255 PMCID: PMC5155334 DOI: 10.1002/adma.201601101
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849