Jiaojiao Lan1, Jun Li2, Xinxin Ju1, Yang Zhou1, Yan Qi1, Yan Ren1, Hong Zou1, Lianghai Wang1, Man Li1, Lijuan Pang1. 1. Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education), Shihezi University School of Medicine, Shihezi, Xinjiang, China. 2. Department of Ultrasonic Medicine, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Abstract
AIM: Several studies have shown that cancer stem cells (CSCs) promote tumor angiogenesis and are involved in tumor growth. A meta-analysis was conducted to evaluate the association between cancer stem cell markers expression and microvessel density (MVD). METHODS: Relevant literature was identified from diverse databases. The Stata 12.0 and Review Manager 5.3 software were used to performed meta-analysis. RESULTS: Sixteen studies investigating the correlation between CSCs and tumor angiogenesis were included in a total of 1409 cases. The result showed that positive CSC markers expression were associated with increased MVD count in human tumors and CSC-transplanted mouse tumor models (p < 0.0001). CONCLUSION: CSCs may be associated with angiogenesis during the growth and development of tumors.
AIM: Several studies have shown that cancer stem cells (CSCs) promote tumor angiogenesis and are involved in tumor growth. A meta-analysis was conducted to evaluate the association between cancer stem cell markers expression and microvessel density (MVD). METHODS: Relevant literature was identified from diverse databases. The Stata 12.0 and Review Manager 5.3 software were used to performed meta-analysis. RESULTS: Sixteen studies investigating the correlation between CSCs and tumor angiogenesis were included in a total of 1409 cases. The result showed that positive CSC markers expression were associated with increased MVD count in humantumors and CSC-transplanted mousetumor models (p < 0.0001). CONCLUSION: CSCs may be associated with angiogenesis during the growth and development of tumors.
Entities:
Keywords:
cancer stem cells; meta-analysis; microvessel density; tumor angiogenesis