Yen-Ping Chen1, Hsiu-Fen Lee2,3, Tai-Tong Wong4. 1. Department of Pediatrics, Taichung Veterans General Hospital, 1650, Taiwan Boulevard Sec. 4, Taichung, 407, Taiwan. 2. Department of Pediatrics, Taichung Veterans General Hospital, 1650, Taiwan Boulevard Sec. 4, Taichung, 407, Taiwan. leehf@hotmail.com.tw. 3. School of Medicine, Chung Shan Medical University, Taichung, Taiwan. leehf@hotmail.com.tw. 4. Department of Pediatric Neurosurgery, Division of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan.
Abstract
PURPOSE: The aim of this study is to describe epileptic seizures in patients with primary intracranial sarcomas. METHODS: We report a 17-year-old girl diagnosed with primary high-grade intracranial sarcoma with initial clinical manifestation of nonconvulsive status epilepticus. Literature reports between 2000 and 2014, relevant to primary intracranial sarcomas in children, were reviewed. The clinical presentations and neurological outcomes were analyzed. RESULTS: Eleven of 29cases (38 %), 8 males and 3 females, who exhibited epileptic seizures as one of the initial symptoms and diagnosed with primary intracranial sarcomas were collected. The median age of disease onset was 5 years. The two most common seizure types were generalized seizures (45 %) and status epilepticus (36 %). Nine of 11 patients (82 %) had tumor growth involving the frontal lobe. Nine cases had the median duration of follow-up 1.7 years, of which 6 cases showed tumor recurrence and 3 cases died during the period of follow-up. CONCLUSIONS: Epileptic seizures as one of the clinical manifestations are uncommon. The two most common seizure types were generalized seizures and status epilepticus. The most frequent location of primary intracranial sarcoma-related seizures was the frontal lobe. The clinical outcome varied.
PURPOSE: The aim of this study is to describe epileptic seizures in patients with primary intracranial sarcomas. METHODS: We report a 17-year-old girl diagnosed with primary high-grade intracranial sarcoma with initial clinical manifestation of nonconvulsive status epilepticus. Literature reports between 2000 and 2014, relevant to primary intracranial sarcomas in children, were reviewed. The clinical presentations and neurological outcomes were analyzed. RESULTS: Eleven of 29cases (38 %), 8 males and 3 females, who exhibited epileptic seizures as one of the initial symptoms and diagnosed with primary intracranial sarcomas were collected. The median age of disease onset was 5 years. The two most common seizure types were generalized seizures (45 %) and status epilepticus (36 %). Nine of 11 patients (82 %) had tumor growth involving the frontal lobe. Nine cases had the median duration of follow-up 1.7 years, of which 6 cases showed tumor recurrence and 3 cases died during the period of follow-up. CONCLUSIONS:Epileptic seizures as one of the clinical manifestations are uncommon. The two most common seizure types were generalized seizures and status epilepticus. The most frequent location of primary intracranial sarcoma-related seizures was the frontal lobe. The clinical outcome varied.
Authors: Martin Benesch; André O von Bueren; Tobias Dantonello; Katja von Hoff; Torsten Pietsch; Ivo Leuschner; Alexander Claviez; Uta Bierbach; Gabriele Kropshofer; Rudolf Korinthenberg; Norbert Graf; Meinolf Suttorp; Rolf Dieter Kortmann; Carsten Friedrich; Nicolas von der Weid; Peter Kaatsch; Thomas Klingebiel; Ewa Koscielniak; Stefan Rutkowski Journal: J Neurooncol Date: 2012-12-11 Impact factor: 4.130
Authors: Ramon Navarro; Astrid Laguna; Carmen de Torres; Juan Cruz Cigudosa; Mariona Suñol; Ofelia Cruz; Jaume Mora Journal: J Neurosurg Date: 2007-11 Impact factor: 5.115