Shruthi Mahalingaiah1, Michael R Winter2, Ann Aschengrau3. 1. Department of Obstetrics and Gynecology, Boston University School of Medicine/Boston Medical Center, 85 E. Concord St., 6th Floor, Boston, MA 02118, USA. Electronic address: shruthi@bu.edu. 2. Data Coordinating Center, Boston University School of Public Health, Fuller 9, 715 Albany Street, Boston MA 02118, USA. Electronic address: mwinter@bu.edu. 3. Department of Epidemiology, Boston University School of Public Health, Talbot 3E, 715 Albany Street, Boston, MA 02118, USA. Electronic address: aaschen@bu.edu.
Abstract
BACKGROUND: Tetrachloroethylene (PCE) is an organic lipophilic solvent with possible neuroendocrine toxicity. The objective of this study was to determine the association of prenatal and early childhood exposure to PCE-contaminated drinking water and development of adult-onset Polycystic Ovary Syndrome (PCOS), endometriosis, difficulty conceiving and miscarriage. METHODS: Five-hundred exposed and 331 unexposed female participants born between 1969 and 1983 completed questionnaires on demographic and lifestyle characteristics, and reproductive disorders. Residential locations from the prenatal period through five years of age were used to estimate early life PCE exposure with water modeling software. RESULTS: For any early life exposure to PCE, the adjusted risk ratio for PCOS was 0.9 (95% CI: 0.5-1.6). No statistically significant associations were observed for increasing levels of exposure with PCOS or the other reproductive disorders. CONCLUSION: No meaningful associations were found among adult women with early life exposure to PCE-contaminated drinking water and adult-onset reproductive disorders.
BACKGROUND:Tetrachloroethylene (PCE) is an organic lipophilic solvent with possible neuroendocrine toxicity. The objective of this study was to determine the association of prenatal and early childhood exposure to PCE-contaminated drinking water and development of adult-onset Polycystic Ovary Syndrome (PCOS), endometriosis, difficulty conceiving and miscarriage. METHODS: Five-hundred exposed and 331 unexposed female participants born between 1969 and 1983 completed questionnaires on demographic and lifestyle characteristics, and reproductive disorders. Residential locations from the prenatal period through five years of age were used to estimate early life PCE exposure with water modeling software. RESULTS: For any early life exposure to PCE, the adjusted risk ratio for PCOS was 0.9 (95% CI: 0.5-1.6). No statistically significant associations were observed for increasing levels of exposure with PCOS or the other reproductive disorders. CONCLUSION: No meaningful associations were found among adult women with early life exposure to PCE-contaminated drinking water and adult-onset reproductive disorders.
Authors: Patricia A Janulewicz; Roberta F White; Brett M Martin; Michael R Winter; Janice M Weinberg; Veronica Vieira; Ann Aschengrau Journal: Neurotoxicol Teratol Date: 2012-04-12 Impact factor: 3.763
Authors: Lisa A Spence; Ann Aschengrau; Lisa E Gallagher; Thomas F Webster; Timothy C Heeren; David M Ozonoff Journal: Environ Health Date: 2008-06-02 Impact factor: 5.984
Authors: Ann Aschengrau; Michael R Winter; Lisa G Gallagher; Veronica M Vieira; Lindsey J Butler; M Patricia Fabian; Jenny L Carwile; Amelia K Wesselink; Shruthi Mahalingaiah; Patricia A Janulewicz; Janice M Weinberg; Thomas F Webster; David M Ozonoff Journal: Environ Sci Process Impacts Date: 2020-02-13 Impact factor: 4.238
Authors: Shruthi Mahalingaiah; J Jojo Cheng; Michael R Winter; Erika Rodriguez; Victoria Fruh; Anna Williams; MyMy Nguyen; Rashmi Madhavan; Pascaline Karanja; Jill MacRae; Sai Charan Konanki; Kevin J Lane; Ann Aschengrau Journal: J Med Internet Res Date: 2021-04-16 Impact factor: 5.428