Literature DB >> 27411923

Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer.

Jian Chen1, Lijuan Hu1, Junjun Wang1, Fan Zhang1, Jie Chen2, Gang Xu1, Yumin Wang3, Qinshi Pan4.   

Abstract

We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression TUBA4B in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.

Entities:  

Keywords:  Non-small cell lung cancer; Prognosis; TUBA4B; lncRNAs

Mesh：

Substances：

Year:  2016        PMID： 27411923     DOI： 10.1007/s12253-016-0089-y

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


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