| Literature DB >> 27411816 |
V V Bekusova1, V M Patsanovskii2, A D Nozdrachev3, V N Anisimov4.
Abstract
It has been shown that metformin dose-dependently inhibits the development of colon tumors induced by 1,2-dimethylhydrazine (DMH) in rats. The metformin effect manifested itself as a decrease in the amount and average size of tumors, increased degree of their differentiation, and reduction of invasion depth, which was more pronounced in the group of animals that received metformin at a dose of 100 mg/kg of body weight as compared with rats treated with metformin at a dose of 300 mg/kg.Entities:
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Year: 2016 PMID： 27411816 DOI： 10.1134/S0012496616030017
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966