Literature DB >> 2740888

A survey of current use of angiotensin-converting-enzyme inhibitors by Scottish physicians in the treatment of chronic cardiac failure.

J McMurray1, C C Lang, D D Maclean, D G McDevitt, A D Struthers.   

Abstract

318 consultant physicians in Scotland were sent a questionnaire on their use of angiotensin converting enzyme (ACE) inhibitors to treat chronic heart failure (CHF). 229 (72%) replies were received. Of these 91% used ACE inhibitors for CHF; 22% were geriatricians, 58% general physicians and 20% cardiologists. All groups reserved ACE inhibitors for patients uncontrolled by diuretics alone. Compared to general physicians, cardiologists used ACE inhibitors in preference to other vasodilators and digoxin, used higher doses and commenced treatment more often on a day-patient basis. Cardiologists also commonly started treatment with captopril even if continuing with enalapril. Geriatricians used ACE inhibitors as frequently as cardiologists but at lower doses; they did not report side-effects more frequently. Further investigation of the safety and possible cost savings of supervised day-patient rather than in-patient, introduction of ACE inhibitors for CHF is now merited. To avoid an extended period of patient observation after the first dose of ACE inhibitor, captopril might also be given as the initial therapy, even if continuing with enalapril. This policy would also reduce the risk of any hypotensive response being prolonged.

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Year:  1989        PMID: 2740888     DOI: 10.1177/003693308903400204

Source DB:  PubMed          Journal:  Scott Med J        ISSN: 0036-9330            Impact factor:   0.729


  5 in total

Review 1.  Tissue and plasma angiotensin converting enzyme and the response to ACE inhibitor drugs.

Authors:  R J MacFadyen; K R Lees; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1991-01       Impact factor: 4.335

2.  Differences in first dose response to angiotensin converting enzyme inhibition in congestive heart failure: a placebo controlled study.

Authors:  R J MacFadyen; K R Lees; J L Reid
Journal:  Br Heart J       Date:  1991-09

3.  Haemodynamic response and pharmacokinetics after the first dose of quinapril in patients with congestive heart failure.

Authors:  I B Squire; R J Macfadyen; K R Lees; W S Hillis; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1994-08       Impact factor: 4.335

Review 4.  The management of heart failure: a matter of definition?

Authors:  A Harley
Journal:  Cardiovasc Drugs Ther       Date:  1993-08       Impact factor: 3.727

5.  Determinants of the blood pressure response to the first dose of ACE inhibitor in mild to moderate congestive heart failure.

Authors:  L Murray; I B Squire; J L Reid; K R Lees
Journal:  Br J Clin Pharmacol       Date:  1998-06       Impact factor: 4.335

  5 in total

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