Katarzyna Kapelko-Slowik1, Donata Urbaniak-Kujda2, Anna Turno-Krecicka3, Stanislaw Potoczek1, Jaroslaw Dybko1, Monika Biernat4, Miroslaw Slowik3. 1. Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland. 2. Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland ; Wroclaw Physiotherapy College, Wroclaw, Poland. 3. Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland. 4. Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367 Wroclaw, Poland ; Department of Microbiology, Wroclaw Medical University, Wroclaw, Poland.
Abstract
PURPOSE: Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis. PATIENT: The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy. The final diagnosis was based on a retinal biopsy. RESULTS: The patient was successfully treated with systemic and local therapy. Long-term complete remission (CR) was reached. The relapse of diffuse large B-cell lymphoma was revealed in the frontal left lobe after 48 months of CR duration. CONCLUSION: The diagnosis of PIOL is always very difficult. Cooperation of pathologists, ophthalmologists and hematologists is required for a quick and accurate diagnosis. Local and systemic treatment is needed to achieve CR, but the relapse rate remains very high.
PURPOSE:Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis. PATIENT: The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy. The final diagnosis was based on a retinal biopsy. RESULTS: The patient was successfully treated with systemic and local therapy. Long-term complete remission (CR) was reached. The relapse of diffuse large B-cell lymphoma was revealed in the frontal left lobe after 48 months of CR duration. CONCLUSION: The diagnosis of PIOL is always very difficult. Cooperation of pathologists, ophthalmologists and hematologists is required for a quick and accurate diagnosis. Local and systemic treatment is needed to achieve CR, but the relapse rate remains very high.
Authors: Chi-Chao Chan; James L Rubenstein; Sarah E Coupland; Janet L Davis; J William Harbour; Patrick B Johnston; Nathalie Cassoux; Valerie Touitou; Justine R Smith; Tracy T Batchelor; Jose S Pulido Journal: Oncologist Date: 2011-11-01
Authors: Mandeep S Sagoo; Hemal Mehta; Andrew J Swampillai; Victoria M L Cohen; Sepideh Z Amin; P Nicholas Plowman; Sue Lightman Journal: Surv Ophthalmol Date: 2013-12-31 Impact factor: 6.048
Authors: Sarah E Coupland; Nikolaos E Bechrakis; Gerasimos Anastassiou; Andreas M H Foerster; Arnd Heiligenhaus; Uwe Pleyer; Michael Hummel; Harald Stein Journal: Graefes Arch Clin Exp Ophthalmol Date: 2003-09-30 Impact factor: 3.117