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Literature DB >> 27408372

CD56 Negative Aggressive T Cell Large Granular Lymphocytic Leukemia.

Mary Theresa Sylvia¹, Sajini Elizabeth Jacob¹, Debdatta Basu¹, Deepak Amalnath², Tarun Kumar Dutta².

Abstract

T cell large granular lymphocytic leukemia is a clonal proliferation of cytotoxic large granular T cells positive for CD3 and CD8. It is a chronic lymphoproliferative disorder with an indolent course. Therapeutic options include observation and low dose chemotherapy. Rarely, they have an aggressive course. Such cases have expression of NK cell associated antigens like CD56 in the T cells. These cases require more aggressive therapy with acute lymphoblastic leukemia regimens. We report a case of fatal CD56 negative T cell large granular lymphocytic leukemia in a 38 year old lady.

Entities: Disease Gene

Keywords: Aggressive variant; CD56 negative; Large granular lymphocytes

Year: 2015 PMID： 27408372 PMCID： PMC4925484 DOI： 10.1007/s12288-015-0502-9

Source DB: PubMed Journal: Indian J Hematol Blood Transfus ISSN： 0971-4502 Impact factor: 0.900

12 in total

1. Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B.

Authors: William G Morice; Paul J Kurtin; Ayalew Tefferi; Curtis A Hanson
Journal: Blood Date: 2002-01-01 Impact factor: 22.113

Review 2. T-cell large granular lymphocyte leukemia and related disorders.

Authors: Michal G Rose; Nancy Berliner
Journal: Oncologist Date: 2004

Review 3. Aggressive T-cell large granular lymphocyte leukemia: a case report and review of the literature.

Authors: Todd J Alekshun; Jianguo Tao; Lubomir Sokol
Journal: Am J Hematol Date: 2007-06 Impact factor: 10.047

4. T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan-T-cell antigens and receptors for MHC molecules.

Authors: Ryan Lundell; Leah Hartung; Sally Hill; Sherrie L Perkins; David W Bahler
Journal: Am J Clin Pathol Date: 2005-12 Impact factor: 2.493

5. Aggressive variant of morphologically typical T large granular lymphocyte leukemia/lymphoma lacking NK cell markers.

Authors: R Passetto Falcão ; B Pinto Simões ; A B Garcia; B A Fonseca; J Terra Filho
Journal: Acta Haematol Date: 2000 Impact factor: 2.195

6. Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice.

Authors: T Lamy; F A Bauer; J H Liu; Y X Li; E Pillemer; H Shahidi; S A Gregory; R Zambello; R Marcolongo; G Semenzato; T P Loughran
Journal: Br J Haematol Date: 2000-03 Impact factor: 6.998

7. Aggressive acute CD3+, CD56- T cell large granular lymphocyte leukemia with two stages of maturation arrest.

Authors: R Tordjman; E Macintyre; J F Emile; F Valensi; V Ribrag; M L Burtin; B Varet; N Brousse; O Hermine
Journal: Leukemia Date: 1996-09 Impact factor: 11.528

Review 8. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990.

Authors: E Weidmann
Journal: Leukemia Date: 2000-06 Impact factor: 11.528

2. CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review.

Authors: M Guerreiro; F Príncipe; M J Teles; S Fonseca; A H Santos; E Fonseca; P Gomes; C Marques; M Lima
Journal: Case Rep Hematol Date: 2017-10-15

2 in total