Literature DB >> 27408257

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy.

M Panwar1, S H Gupta2.   

Abstract

BACKGROUND: Scaling and root planing is the basic treatment modality for periodontal disease. Mechanical treatment is limited by physical impediments and biochemical considerations. Antimicrobial agents may be used as an adjunct to overcome limitations of mechanical therapy.
METHODS: A case-control study was carried out on 30 patients suffering from chronic periodontitis. In Group A only scaling and root planing was carried out whereas in Group B tetracycline fibers were used along with scaling and root planing. RESULT: Tetracycline fibers as an adjunct to scaling and root planing was found to be more effective in reducing inflammation. The number of sites with bleeding on probing were 12 in Group A as compared to four in Group B after 30 days. The mean decrease in probing depth was more in Group B than Group A after 30 and 90 days. General linear model showed that decrease in probing depth was statistically significant with both mechanical therapy as well as adjunctive use of tetracycline fibers.
CONCLUSION: Local drug delivery with tetracycline fiber is an effective and simple non surgical method to improve periodontal health which can be practiced even by a general dental practitioner.

Entities:  

Keywords:  Bleeding on probing; Mechanical therapy; Probing depth; Tetracycline fibers

Year:  2011        PMID: 27408257      PMCID: PMC4921381          DOI: 10.1016/S0377-1237(09)80014-2

Source DB:  PubMed          Journal:  Med J Armed Forces India        ISSN: 0377-1237


  12 in total

Review 1.  Use of antimicrobial agents during supportive periodontal therapy.

Authors:  E Venezia; L Shapira
Journal:  Oral Dis       Date:  2003       Impact factor: 3.511

Review 2.  Non-surgical pocket therapy: pharmacotherapeutics.

Authors:  C H Drisko
Journal:  Ann Periodontol       Date:  1996-11

3.  Local tetracycline delivery using hollow fiber devices in periodontal therapy.

Authors:  J Lindhe; L Heijl; J M Goodson; S S Socransky
Journal:  J Clin Periodontol       Date:  1979-06       Impact factor: 8.728

4.  Local versus systemic adjunctive antibiotic therapy in 28 patients with generalized aggressive periodontitis.

Authors:  P Purucker; H Mertes; J M Goodson; J P Bernimoulin
Journal:  J Periodontol       Date:  2001-09       Impact factor: 6.993

5.  Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results.

Authors:  A Mombelli; A Feloutzis; U Brägger; N P Lang
Journal:  Clin Oral Implants Res       Date:  2001-08       Impact factor: 5.977

6.  Antimicrobial therapy using a local drug delivery system (Arestin) in the treatment of peri-implantitis. I: Microbiological outcomes.

Authors:  G Rutger Persson; Giovanni E Salvi; Lisa J A Heitz-Mayfield; Niklaus P Lang
Journal:  Clin Oral Implants Res       Date:  2006-08       Impact factor: 5.977

7.  Periodontal therapy by local delivery of tetracycline.

Authors:  J M Goodson; A Haffajee; S S Socransky
Journal:  J Clin Periodontol       Date:  1979-04       Impact factor: 8.728

8.  Antibiotic resistance profile of the subgingival microbiota following systemic or local tetracycline therapy.

Authors:  Rosa Maria J Rodrigues; Cristiane Gonçalves; Renata Souto; Eduardo Jorge Feres-Filho; Milton Uzeda; Ana Paula V Colombo
Journal:  J Clin Periodontol       Date:  2004-06       Impact factor: 8.728

9.  Meta-analysis of local tetracycline in treating chronic periodontitis.

Authors:  Maria Pavia; Carmelo G A Nobile; Italo F Angelillo
Journal:  J Periodontol       Date:  2003-06       Impact factor: 6.993

10.  Monolithic tetracycline-containing fibers for controlled delivery to periodontal pockets.

Authors:  J M Goodson; D Holborow; R L Dunn; P Hogan; S Dunham
Journal:  J Periodontol       Date:  1983-10       Impact factor: 6.993

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  4 in total

1.  Formulation, Evaluation, and Clinical Assessment of Novel Solid Lipid Microparticles of Tetracycline Hydrochloride for the Treatment of Periodontitis.

Authors:  Rajkiran Narkhede; Rajani Athawale; Nikita Patil; MalaDixit Baburaj
Journal:  AAPS PharmSciTech       Date:  2021-05-24       Impact factor: 3.246

Review 2.  Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications.

Authors:  Daniela Coppola; Maria Oliviero; Giovanni Andrea Vitale; Chiara Lauritano; Isabella D'Ambra; Salvatore Iannace; Donatella de Pascale
Journal:  Mar Drugs       Date:  2020-04-15       Impact factor: 5.118

3.  Comparison of efficacy of probiotics versus tetracycline fibers as adjuvants to scaling and root planing.

Authors:  Lavanya Boyeena; Rekha Rani Koduganti; Veerendranath Reddy Panthula; Surya Prasanna Jammula
Journal:  J Indian Soc Periodontol       Date:  2019 Nov-Dec

4.  Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration.

Authors:  Zhuanzhuan Yang; Xin Liang; Xiaojing Jiang; Jian Guo; Yaotian Tao; Shengmei Wang; Yingji Cao; Shuangying Gui
Journal:  Molecules       Date:  2018-09-06       Impact factor: 4.411

  4 in total

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