D Saldanha1, N Kumar2, Vssr Ryali3, K Srivastava4, A A Pawar5. 1. Commandant, 92 Base Hosp C/o-56 APO. 2. Graded Specialist (Psychiatry), MH Jhansi. 3. Senior Advisor (Psychiatry), INHS Asvini, Colaba, Mumbai. 4. Scientist 'E' (Department of Psychiatry), AFMC, Pune. 5. Commanding Officer, INHS Sanjivani, Kochi.
Abstract
BACKGROUND: Serotonin plays an important role in treatment of depression. We evaluated the clinical correlates of plasma serotonin levels in depressed patients before and after treatment. METHODS: Study sample comprised of 40 patients diagnosed on ICD-10 diagnostic criteria, and an equal number of healthy matched controls. Subjects were evaluated on Beck's Depression Inventory (BDI) and Suicide Ideation Scale (SIS), before and after the treatment. Blood samples were collected from all the cases and controls before starting the antidepressant medication with selective serotonin reuptake inhibitors (SSRI's). Serum serotonin levels were measured before and after treatment. RESULT: Significant differences in scores before and after the intervention on BDI, SIS and serotonin levels of cases and controls (p<.000) were noted. Correlation between the serum serotonin levels before and after the treatment, and between the rating scales did not reveal significant association (p > 0.05). Patients with suicidal intentions had lower levels of serotonin. The scores changed after intervention. CONCLUSION: Treatment with SSRI's had shown significant changes in clinical conditions. However these changes did not relate significantly with serum serotonin levels.
BACKGROUND:Serotonin plays an important role in treatment of depression. We evaluated the clinical correlates of plasma serotonin levels in depressedpatients before and after treatment. METHODS: Study sample comprised of 40 patients diagnosed on ICD-10 diagnostic criteria, and an equal number of healthy matched controls. Subjects were evaluated on Beck's Depression Inventory (BDI) and Suicide Ideation Scale (SIS), before and after the treatment. Blood samples were collected from all the cases and controls before starting the antidepressant medication with selective serotonin reuptake inhibitors (SSRI's). Serum serotonin levels were measured before and after treatment. RESULT: Significant differences in scores before and after the intervention on BDI, SIS and serotonin levels of cases and controls (p<.000) were noted. Correlation between the serum serotonin levels before and after the treatment, and between the rating scales did not reveal significant association (p > 0.05). Patients with suicidal intentions had lower levels of serotonin. The scores changed after intervention. CONCLUSION: Treatment with SSRI's had shown significant changes in clinical conditions. However these changes did not relate significantly with serum serotonin levels.
Authors: Jonathan RT Davidson; Kishore M Gadde; John A Fairbank; K Ranga Rama Krishnan; Robert M Califf; Cynthia Binanay; Corette B Parker; Norma Pugh; Tyler D Hartwell; Benedetto Vitiello; Louise Ritz; Joanne Severe; Jonathan O Cole; Charles de Battista; P Murali Doraiswamy; John P Feighner; Paul Keck; Jeffrey Kelsey; Khae-Ming Lin; Peter D Londborg; Charles B Nemeroff; Alan F Schatzberg; David V Sheehan; Ram K Srivastava; Leslie Taylor; Madhukar H Trivedi; Richard H Weisler Journal: JAMA Date: 2002-04-10 Impact factor: 56.272
Authors: Olga V Averina; Yana A Zorkina; Roman A Yunes; Alexey S Kovtun; Valeriya M Ushakova; Anna Y Morozova; George P Kostyuk; Valery N Danilenko; Vladimir P Chekhonin Journal: Int J Mol Sci Date: 2020-12-03 Impact factor: 5.923
Authors: Enrique Becerril-Villanueva; María Irma Olvera-Alvarez; Samantha Alvarez-Herrera; Jose Luis Maldonado-García; Adolfo López-Torres; Oscar Abelardo Ramírez-Marroquín; Octavio González-Ruiz; José Manuel Nogueira-Fernández; José Manuel Mendoza-Contreras; Héctor Omar Sánchez-García; José Antonio José-Alfallo; Atenodoro Valencia Baños; Ana Berta Torres-Serrano; Janeth Jiménez-Genchi; Danelia Mendieta-Cabrera; Gilberto Pérez-Sánchez; Lenin Pavón Journal: Front Psychiatry Date: 2022-03-23 Impact factor: 4.157