Rajvir Bhalwar1, V C Ohri2, B L Somani3, A S Kasthuri4. 1. Prof and Head, Dept of PSM, AFMC, Pune 411 040. 2. Ex-Conslt and Head, Dept of Microbiology, AFMC, Pune. 3. Scientist 'F' and Prof, Dept of Biochemistry, AFMC, Pune 411 040. 4. Ex -Prof and Head, Dept of Medicine, AFMC, Pune 411 040.
Abstract
BACKGROUND: Syndrome 'X', a clustering of impaired glucose tolerance (IGT), raised blood pressure, raised serum triglycerides and low HDL-cholesterol, occurring under the influence of insulin resistance and resultant hyperinsulinaemia, has been hypothesised to be a major risk factor for ischaemic heart disease (IHD). However, there is a lack of research based evidence in this field, in our country. METHODS: The study was a cross-sectional analytical epidemiological design of 614 healthy Indian Army personnel, aged 35 years and above, selected by random sampling. RESULTS: The study indicated that there is a statistically significant (p < 0.001) clustering between fasting hyperinsulinaemia, raised blood pressure, IGT, raised triglycerides and low HDL. The prevalence of syndrome 'X' was 8.47% (95% CI 6.27% to 10.47%). Initial univariate and subsequent multivariate analysis using multiple logistic regression method, indicated that predictors of syndrome 'X' were increasing age, overweight, increasing central (abdominal) obesity, lack of adequate physical exercise and low level of physical fitness. Presence of syndrome 'X' increased the risk of resting ECG changes suggestive of coronary insufficiency (OR = 6.29, p < 0.001). CONCLUSION: Based on the findings, recommendations for prevention of this syndrome have been submitted.
BACKGROUND: Syndrome 'X', a clustering of impaired glucose tolerance (IGT), raised blood pressure, raised serum triglycerides and low HDL-cholesterol, occurring under the influence of insulin resistance and resultant hyperinsulinaemia, has been hypothesised to be a major risk factor for ischaemic heart disease (IHD). However, there is a lack of research based evidence in this field, in our country. METHODS: The study was a cross-sectional analytical epidemiological design of 614 healthy Indian Army personnel, aged 35 years and above, selected by random sampling. RESULTS: The study indicated that there is a statistically significant (p < 0.001) clustering between fasting hyperinsulinaemia, raised blood pressure, IGT, raised triglycerides and low HDL. The prevalence of syndrome 'X' was 8.47% (95% CI 6.27% to 10.47%). Initial univariate and subsequent multivariate analysis using multiple logistic regression method, indicated that predictors of syndrome 'X' were increasing age, overweight, increasing central (abdominal) obesity, lack of adequate physical exercise and low level of physical fitness. Presence of syndrome 'X' increased the risk of resting ECG changes suggestive of coronary insufficiency (OR = 6.29, p < 0.001). CONCLUSION: Based on the findings, recommendations for prevention of this syndrome have been submitted.
Authors: F H EPSTEIN; L D OSTRANDER; B C JOHNSON; M W PAYNE; N S HAYNER; J B KELLER; T FRANCIS Journal: Ann Intern Med Date: 1965-06 Impact factor: 25.391
Authors: A Fontbonne; M A Charles; N Thibult; J L Richard; J R Claude; J M Warnet; G E Rosselin; E Eschwège Journal: Diabetologia Date: 1991-05 Impact factor: 10.122