A K Praharaj1, S Tripathy2, A K Kalghatgi3, A Nagendra4. 1. Senior Advisor(Pathology), CH (SC) Pune - 40. 2. Classified Speciality(Pathology), CH (EC) Kolkata. 3. Senior Advisor(Pathology), Command Hospital (Central Command), Lucknow. 4. Dy Commandant, Command Hospital (Western Command) Chandimandir.
Abstract
BACKGROUND: A new RNA virus designated hepatitis G virus (HGV) was recently identified. Because HGV has less than 25% sequence or amino acid homology with hepatitis C virus (HCV) and other established Flaviviridae, it is considered to be a new genus in this growing family of hapatotropic viruses. Hepatitis G virus has been associated with hepatitis and is transmitted through parenteral and sexual route. MATERIAL AND METHODS: A study comprising 500 healthy voluntary blood donors (service personnel) was under taken to find out prevalence of HGV. HGV RNA was detected by reverse transcriptase - polymerase chain reaction (RT-PCR). Hepatitis B surface antigen (HbsAg) and antibody to HCV were detected by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: Thirteen donors (2.6%) were positive for HGV RNA. 17 donors (3.4%) were positive for antibody to hepatitis C virus (HCV) by ELISA. Co-infection of HGV with hepatitis B virus (HBV) was seen in 5 donors and with HCV infection in 2 donors. Co-infection of HGV, HBV and HCV was not seen in any donor. CONCLUSION: So far there is no conclusive evidence that HGV produces hepatitis. But presence of HGV in hepatitis cases casts a doubt on this finding. Prevalence rate in blood donors may be helpful in future studies when the exact role of HGV is known.
BACKGROUND: A new RNA virus designated hepatitis G virus (HGV) was recently identified. Because HGV has less than 25% sequence or amino acid homology with hepatitis C virus (HCV) and other established Flaviviridae, it is considered to be a new genus in this growing family of hapatotropic viruses. Hepatitis G virus has been associated with hepatitis and is transmitted through parenteral and sexual route. MATERIAL AND METHODS: A study comprising 500 healthy voluntary blood donors (service personnel) was under taken to find out prevalence of HGV. HGV RNA was detected by reverse transcriptase - polymerase chain reaction (RT-PCR). Hepatitis B surface antigen (HbsAg) and antibody to HCV were detected by Enzyme Linked Immunosorbent Assay (ELISA). RESULTS: Thirteen donors (2.6%) were positive for HGV RNA. 17 donors (3.4%) were positive for antibody to hepatitis C virus (HCV) by ELISA. Co-infection of HGV with hepatitis B virus (HBV) was seen in 5 donors and with HCV infection in 2 donors. Co-infection of HGV, HBV and HCV was not seen in any donor. CONCLUSION: So far there is no conclusive evidence that HGV produces hepatitis. But presence of HGV in hepatitis cases casts a doubt on this finding. Prevalence rate in blood donors may be helpful in future studies when the exact role of HGV is known.
Entities:
Keywords:
Armed Forces; Blood donors; Hepatitis G Virus
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