Sps Kochar1, P Arora2, A B Chattopadhyay3. 1. Reader (Obstetric and Gynaecology), Armed Forces Medical College, Pune. 2. Director General Medical Services (Navy), Naval Headquarters, New Delhi. 3. Ex-Commandant, CH (NC), c/o 56 APO.
Abstract
BACKGROUND: Tamoxifen, used as adjuvant therapy for carcinoma breast in postmenopausal women to prevent relapse has estrogenic effect on the endometrium. METHODS: 104 patients on tamoxifen for more than six months were subjected to a clinical examination and transvaginal sonography. Patients with endometrial thickness > 8 mm were further evaluated by hysteroscopy and endometrial biopsy. RESULTS: 35(34%) patients were symptomatic. The average endometrial thickness was 11.2 mm which correlated with duration of tamoxifen use. 27(48%) patients had abnormal hysteroscopic findings. 35 (63%) of endometrial biopsies revealed abnormal endometrium. One case of endometrial carcinoma was diagnosed. The results were statistically analysed. There is a significant association between symptomatic status and endometrial thickness and duration of tamoxifen use. CONCLUSION: All patients on long term tamoxifen should be annually screened for endometrial pathology.
BACKGROUND:Tamoxifen, used as adjuvant therapy for carcinoma breast in postmenopausal women to prevent relapse has estrogenic effect on the endometrium. METHODS: 104 patients on tamoxifen for more than six months were subjected to a clinical examination and transvaginal sonography. Patients with endometrial thickness > 8 mm were further evaluated by hysteroscopy and endometrial biopsy. RESULTS: 35(34%) patients were symptomatic. The average endometrial thickness was 11.2 mm which correlated with duration of tamoxifen use. 27(48%) patients had abnormal hysteroscopic findings. 35 (63%) of endometrial biopsies revealed abnormal endometrium. One case of endometrial carcinoma was diagnosed. The results were statistically analysed. There is a significant association between symptomatic status and endometrial thickness and duration of tamoxifen use. CONCLUSION: All patients on long term tamoxifen should be annually screened for endometrial pathology.
Authors: M Seoud; A Shamseddine; A Khalil; Z Salem; N Saghir; K Bikhazi; N Bitar; G Azar; H Kaspar Journal: Gynecol Oncol Date: 1999-10 Impact factor: 5.482
Authors: L Bernstein; D Deapen; J R Cerhan; S M Schwartz; J Liff; E McGann-Maloney; J A Perlman; L Ford Journal: J Natl Cancer Inst Date: 1999-10-06 Impact factor: 13.506