P Sultanik1,2,3,4, L Kramer2,3, D Soudan2,3, S Bouam2,5, J-F Meritet2,6, A Vallet-Pichard2,3,4, H Fontaine2,3,4, L Bousquet2,3, E Boueyre2,3, M Corouge2,3, P Sogni1,2,3,4, S Pol1,2,3,4, V Mallet1,2,3,4. 1. Université Paris Descartes, Paris, France. 2. Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe Hospitalier Cochin Port Royal, Paris, France. 3. Hepatology Service, Paris, France. 4. Institut National de la Santé et de la Recherche Médicale Unité 1223, Institut Pasteur, Paris, France. 5. Medical Information Service, Paris, France. 6. Virology Service, Paris, France.
Abstract
BACKGROUND: There is a relationship between liver stiffness measurement (LSM) and outcome of HCV patients. AIM: To evaluate the performance of LSM to predict outcome of HCV patients at risk of liver-related complication. METHODS: We established a retrospective longitudinal cohort of 341 HCV patients with unequivocal cirrhosis. All underwent LSM and were followed from September 2006 to July 2015. Outcome measure was a composite end-point of end-stage liver disease (ESLD) and/or hepatocellular carcinoma (HCC). Cox models and areas under receiver operating characteristic (AUROC) curves were used to evaluate independent risk factors of outcome. RESULTS: Overall, LSM was below the 12.5 kPa threshold in 129 (37.8%) patients, including three-fourth and one-third of patients with or without a sustained virological response respectively. Liver disease progressed in 136 (39.9%) patients after a median observational period of 23.5 months. Older age, male gender, alcohol use disorders, metabolic syndrome and LSM were independent risk factors of liver disease progression. Age, alcohol use disorders and LSM were independently associated with ESLD. Age, gender and metabolic syndrome, but not LSM, were associated with HCC. The AUROC curves for disease progression, ESLD and HCC were 0.67, 0.70 and 0.58 respectively. Patients with a liver stiffness >12.5 kPa were at the highest risk of liver disease progression; below 12.5 kPa, liver stiffness was not discriminant. CONCLUSION: Liver stiffness measurement is not a surrogate of disease progression of HCV patients with cirrhosis. HCV patients with cirrhosis should undergo the recommended follow-up, regardless of liver stiffness measurement.
BACKGROUND: There is a relationship between liver stiffness measurement (LSM) and outcome of HCVpatients. AIM: To evaluate the performance of LSM to predict outcome of HCVpatients at risk of liver-related complication. METHODS: We established a retrospective longitudinal cohort of 341 HCVpatients with unequivocal cirrhosis. All underwent LSM and were followed from September 2006 to July 2015. Outcome measure was a composite end-point of end-stage liver disease (ESLD) and/or hepatocellular carcinoma (HCC). Cox models and areas under receiver operating characteristic (AUROC) curves were used to evaluate independent risk factors of outcome. RESULTS: Overall, LSM was below the 12.5 kPa threshold in 129 (37.8%) patients, including three-fourth and one-third of patients with or without a sustained virological response respectively. Liver disease progressed in 136 (39.9%) patients after a median observational period of 23.5 months. Older age, male gender, alcohol use disorders, metabolic syndrome and LSM were independent risk factors of liver disease progression. Age, alcohol use disorders and LSM were independently associated with ESLD. Age, gender and metabolic syndrome, but not LSM, were associated with HCC. The AUROC curves for disease progression, ESLD and HCC were 0.67, 0.70 and 0.58 respectively. Patients with a liver stiffness >12.5 kPa were at the highest risk of liver disease progression; below 12.5 kPa, liver stiffness was not discriminant. CONCLUSION: Liver stiffness measurement is not a surrogate of disease progression of HCVpatients with cirrhosis. HCVpatients with cirrhosis should undergo the recommended follow-up, regardless of liver stiffness measurement.
Authors: Harrys A Torres; Terri Lynn Shigle; Nassim Hammoudi; James T Link; Felipe Samaniego; Ahmed Kaseb; Vincent Mallet Journal: CA Cancer J Clin Date: 2017-07-06 Impact factor: 508.702
Authors: Ana Zaida Gomez-Moreno; Daniel Pineda-Tenor; Maria Angeles Jimenez-Sousa; Juan Jose Sánchez-Ruano; Tomas Artaza-Varasa; Jose Saura-Montalban; Pablo Ryan; Salvador Resino Journal: PLoS One Date: 2017-09-07 Impact factor: 3.240