Weiwei Wu1, Hailan Yang2, Yongliang Feng1, Ping Zhang1, Shuzhen Li3, Xin Wang4, Tingting Peng1, Fang Wang1, Bingjie Xie1, Pengge Guo1, Mei Li1, Ying Wang1, Nan Zhao5, Dennis Wang5, Suping Wang6, Yawei Zhang7,8. 1. Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. 2. Department of Obstetrics, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China. 3. Department of Information, the First Affiliated Hospital, Shanxi Medical University, Taiyuan, China. 4. Center for Disease Control and Prevention, Taiyuan Railway Administration, Taiyuan, China. 5. Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA. 6. Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. spwang88@163.com. 7. Department of Epidemiology, Shanxi Medical University School of Public Health, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. yawei.zhang@yale.edu. 8. Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven, CT, 06520, USA. yawei.zhang@yale.edu.
Abstract
BACKGROUND AND OBJECTIVES: Altered immune response may be a part of the pathogenesis of preeclampsia. The few epidemiologic studies that have investigated the associations between genetic variations in the complement system genes and preeclampsia risk have reached inconsistent results. The aim of this study is to determine if polymorphisms in the complement system genes could influence the risk of preeclampsia. METHODS: We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study of 203 preeclampsia cases and 233 controls. RESULTS: Both C6 and MASP1 were associated with the risk of preeclampsia. C6 (rs7444800, rs4957381) and MASP1 (rs1108450, rs3774282, rs698106) polymorphisms were associated with the risk of early-onset preeclampsia and severe preeclampsia, while MASP1 (rs1357134, rs698090) polymorphisms were associated with the risk of late-onset preeclampsia and severe preeclampsia. CONCLUSIONS: Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes.
BACKGROUND AND OBJECTIVES: Altered immune response may be a part of the pathogenesis of preeclampsia. The few epidemiologic studies that have investigated the associations between genetic variations in the complement system genes and preeclampsia risk have reached inconsistent results. The aim of this study is to determine if polymorphisms in the complement system genes could influence the risk of preeclampsia. METHODS: We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case-control study of 203 preeclampsia cases and 233 controls. RESULTS: Both C6 and MASP1 were associated with the risk of preeclampsia. C6 (rs7444800, rs4957381) and MASP1 (rs1108450, rs3774282, rs698106) polymorphisms were associated with the risk of early-onset preeclampsia and severe preeclampsia, while MASP1 (rs1357134, rs698090) polymorphisms were associated with the risk of late-onset preeclampsia and severe preeclampsia. CONCLUSIONS: Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes.
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