György M Buzás1, Judith Konderák2. 1. Ferencváros Health Centre, Gastroenterology, Budapest, Hungary. 2. Synlab Ltd, Budapest, Hungary.
Abstract
BACKGROUND: Some gastric cancers are Epstein-Barr virus associated. AIM: To assess the prevalence of Helicobacter pylori and viral co-infection in benign upper digestive diseases. METHODS: One hundred and four outpatients were included in a prospective endoscopic-serologic study. Epstein-Barr virus immunoglobulin G (IgG), immunoglobulin M and viral capsid antigen titres were assayed with an ELISA test. Helicobacter pylori was determined by the modified Giemsa stain and by IgG-chemiluminescence. RESULTS: The overall prevalence of Helicobacter pylori was 56.7%. Duodenal ulcer patients were infected in 72.5 % of the cases, with the prevalence being 33.3% in functional dyspepsia (p = 0.0008) and 25.8% in reflux patients (p = 0.0001). Epstein-Barr virus IgG was detected in 70.1% of the whole group, 75% of duodenal ulcer patients, 51.2% of functional dyspepsia patients (p = 0.04) and 51.6% of the reflux disease cases (p = 0.04). Co-infection with both agents was detected in 60% of duodenal ulcer patients, 18.1% of functional dyspepsia (p = 0.00014) and 12.9% of reflux disease patients (p = 0.00012). Anti-viral IgG titre displayed a 31.7 ± 3.0 cut-off index in duodenal ulcer, 20.5 ± 3.5 in functional dyspepsia (p = 0.01) and 21.4 ± 3.6 in reflux cases (p = 0.03). CONCLUSIONS: Both Helicobacter pylori and Epstein-Barr virus, and co-infection with these agents, were significantly more prevalent in duodenal ulcer patients than in dyspeptic/reflux patients.
BACKGROUND: Some gastric cancers are Epstein-Barr virus associated. AIM: To assess the prevalence of Helicobacter pylori and viral co-infection in benign upper digestive diseases. METHODS: One hundred and four outpatients were included in a prospective endoscopic-serologic study. Epstein-Barr virus immunoglobulin G (IgG), immunoglobulin M and viral capsid antigen titres were assayed with an ELISA test. Helicobacter pylori was determined by the modified Giemsa stain and by IgG-chemiluminescence. RESULTS: The overall prevalence of Helicobacter pylori was 56.7%. Duodenal ulcerpatients were infected in 72.5 % of the cases, with the prevalence being 33.3% in functional dyspepsia (p = 0.0008) and 25.8% in reflux patients (p = 0.0001). Epstein-Barr virus IgG was detected in 70.1% of the whole group, 75% of duodenal ulcerpatients, 51.2% of functional dyspepsiapatients (p = 0.04) and 51.6% of the reflux disease cases (p = 0.04). Co-infection with both agents was detected in 60% of duodenal ulcerpatients, 18.1% of functional dyspepsia (p = 0.00014) and 12.9% of reflux diseasepatients (p = 0.00012). Anti-viral IgG titre displayed a 31.7 ± 3.0 cut-off index in duodenal ulcer, 20.5 ± 3.5 in functional dyspepsia (p = 0.01) and 21.4 ± 3.6 in reflux cases (p = 0.03). CONCLUSIONS: Both Helicobacter pylori and Epstein-Barr virus, and co-infection with these agents, were significantly more prevalent in duodenal ulcerpatients than in dyspeptic/reflux patients.
Authors: Juan L E Martínez-López; Javier Torres; Margarita Camorlinga-Ponce; Alejandra Mantilla; Yelda A Leal; Ezequiel M Fuentes-Pananá Journal: Viruses Date: 2014-01-20 Impact factor: 5.048
Authors: A Reiman; J E Powell; K J Flavell; R G Grundy; J R Mann; S Parkes; D Redfern; L S Young; P G Murray Journal: Br J Cancer Date: 2003-10-06 Impact factor: 7.640