Literature DB >> 27402586

Dermatomyositis as a paraneoplastic phenomenon in ovarian cancer.

Ilyas Arshad1, Desmond Barton1.   

Abstract

A 60-year-old woman diagnosed with papillary serous ovarian cancer had Klean-Prep and MRI contrast preoperatively. Afterwards, she developed swelling and an urticarial rash around her eye as she proceeded to have planned debulking surgery. Postoperatively the swelling and rash had spread over her face, neck, back and chest. Dermatology advised a possible allergy to Klean-Prep and MRI contrast. Subsequently over the next few months, the patient became severely debilitated from proximal myopathy of the upper and lower limbs, suffered severe pain restricting mobility and small bowel obstruction. Medical oncologist reviewed the patient, clinically diagnosed dermatomyositis and initiated treatment with high-dose intravenous steroids, resulting in remission of the patient's condition. The main purpose of this study is to describe the severity, diagnostic challenges and underline the clinical significance of dermatomyositis manifestations as a paraneoplastic effect in patients with ovarian cancer. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27402586      PMCID: PMC4956992          DOI: 10.1136/bcr-2016-215463

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  6 in total

Review 1.  Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis.

Authors:  Angela B Robinson; Ann M Reed
Journal:  Nat Rev Rheumatol       Date:  2011-09-27       Impact factor: 20.543

2.  Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study.

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Journal:  Lancet       Date:  2001-01-13       Impact factor: 79.321

3.  Serum CA-125 screening for ovarian cancer in patients with dermatomyositis.

Authors:  S E Whitmore; G J Anhalt; T T Provost; H A Zacur; U M Hamper; K J Helzlsouer; N B Rosenshein
Journal:  Gynecol Oncol       Date:  1997-05       Impact factor: 5.482

4.  Adenocarcinoma of the colon presenting as polymyositis: case report.

Authors:  N Tsavaris; G Karargyris; D Pikazis; M Vadiaka; C Kosmas; N Sakellaropoulos; G Vaiopoulos
Journal:  J Chemother       Date:  2002-02       Impact factor: 1.714

5.  Dermatomyositis: a clinicopathological study of 40 patients.

Authors:  Edward S Smith; James R Hallman; Amena M DeLuca; Gary Goldenberg; Joseph L Jorizzo; Omar P Sangueza
Journal:  Am J Dermatopathol       Date:  2009-02       Impact factor: 1.533

6.  Dermatomyositis as presenting feature of ovarian cancer, treated with neo-adjuvant chemotherapy and interval debulking surgery.

Authors:  Alan Christie; Neil McKay; Fiona Nussey
Journal:  Gynecol Oncol Case Rep       Date:  2013-07-16
  6 in total
  4 in total

1.  Dermatomyositis - key to diagnosing ovarian cancer, monitoring treatment and detecting recurrent disease: Case report.

Authors:  Carlie Field; Barbara A Goff
Journal:  Gynecol Oncol Rep       Date:  2017-11-28

2.  Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera.

Authors:  Naomi Fei; Sarah Sofka
Journal:  Case Rep Hematol       Date:  2017-06-04

3.  Spontaneous resolution of dermatomyositis associated with fallopian-tube carcinoma following staging surgery: A case report.

Authors:  Chen Lin; Zheng Ying; Chen Sijing
Journal:  Medicine (Baltimore)       Date:  2019-03       Impact factor: 1.817

4.  Rapid development and use of patient-specific ctDNA biomarkers to avoid a "rash decision" in an ovarian cancer patient.

Authors:  Deep Pandya; Sandra Catalina Camacho; Maria M Padron; Olga Camacho-Vanegas; Jean-Noel Billaud; Ann-Marie Beddoe; Jon Irish; Lorene Yoxtheimer; Tamara Kalir; Jordan RoseFigura; Peter Dottino; John A Martignetti
Journal:  Cold Spring Harb Mol Case Stud       Date:  2019-12-13
  4 in total

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