Jian Yang1, Ying Zhu1, Liangquan Wu1, Wenyan Zhu1, Xiuwei Zhang1, Yang Yang1, Chunhua Xu2,3. 1. Department of Respiratory Medicine, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, 211100, China. 2. Endoscopic Center of Nanjing Chest Hospital, Nanjing, Jiangsu, 210029, China. 3. Clinical Center of Nanjing Respiratory Diseases and Imaging, Nanjing, Jiangsu, 210029, China.
Abstract
OBJECTIVES: This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble receptor-binding cancer antigen expressed on SiSo cells (sRCAS1) in lung cancer patients with malignant pleural effusion (MPE). METHODS: Pleural effusion samples were collected from 78 patients with MPE, and from 48 patients with benign pleural effusion (BPE). Pleural effusion sRCAS1 concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: MPE has significantly higher sRCAS1 levels than that of BPE (P < .01). With a cutoff value of 18.7 U/mL, sRCAS1 showed a good diagnostic performance for MPE. Univariate and multivariate analysis indicated that elevated sRCAS1 levels were an independent predictor of overall survival (OS) and disease-free survival (DFS). Kaplan-Meier survival curves further confirmed that patients with high sRCAS1 have shorter DFS and OS (P = .026 and P = .032, respectively). CONCLUSION: In conclusion, measurement of sRCAS1 might be a useful diagnostic and prognostic marker for MPE.
OBJECTIVES: This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble receptor-binding cancer antigen expressed on SiSo cells (sRCAS1) in lung cancerpatients with malignant pleural effusion (MPE). METHODS:Pleural effusion samples were collected from 78 patients with MPE, and from 48 patients with benign pleural effusion (BPE). Pleural effusion sRCAS1 concentrations were measured by enzyme-linked immunosorbent assay. RESULTS: MPE has significantly higher sRCAS1 levels than that of BPE (P < .01). With a cutoff value of 18.7 U/mL, sRCAS1 showed a good diagnostic performance for MPE. Univariate and multivariate analysis indicated that elevated sRCAS1 levels were an independent predictor of overall survival (OS) and disease-free survival (DFS). Kaplan-Meier survival curves further confirmed that patients with high sRCAS1 have shorter DFS and OS (P = .026 and P = .032, respectively). CONCLUSION: In conclusion, measurement of sRCAS1 might be a useful diagnostic and prognostic marker for MPE.