Amy Christine Brown1. 1. Department of Complementary and Alternative Medicine, John A. Burns School of Medicine, 651 Ilalo Street, MEB 223, University of Hawaii at Manoa, Honolulu, HI, 96813, USA. Electronic address: amybrown@hawaii.edu.
Abstract
BACKGROUND: No online current list of potentially life-threatening, hepatotoxic herbs and dietary supplements based on PubMed case reports exists in a summarized tabular form. METHODS: Documented case reports of herbs or dietary supplements (DS; includes herbs) appearing to contribute to liver injury were used to create an online "DS Toxic Table" of potentially hepatotoxic herbs and dietary supplements (PubMed, 1966 to June, 2016, and cross-referencing). The spectrum of DS induced liver injuries (DSILI) included elevated liver enzymes, hepatitis, steatosis, cholestasis, hepatic necrosis, hepatic fibrosis, hepatic cirrhosis, veno-occlusive disease, acute liver failure requiring a liver transplant, and death. RESULTS: Over the past 50 years, approximately 21 herbs (minus germander and usnic acid that are no longer sold) and 12 dietary supplements (minus the nine no longer sold and vitamin A & niacin due to excess intake) posed a possible risk for liver injures in certain individuals. The herbs with the most number of reported publications (but not cases studies) in descending order, were germander, black cohosh, kava extract, and green tea extract. CONCLUSION: These online DS Toxic Tables will contribute to continued Phase IV post marketing surveillance to detect possible liver toxicity cases and serve to forewarn consumers, clinicians, and corporations.
BACKGROUND: No online current list of potentially life-threatening, hepatotoxic herbs and dietary supplements based on PubMed case reports exists in a summarized tabular form. METHODS: Documented case reports of herbs or dietary supplements (DS; includes herbs) appearing to contribute to liver injury were used to create an online "DS Toxic Table" of potentially hepatotoxic herbs and dietary supplements (PubMed, 1966 to June, 2016, and cross-referencing). The spectrum of DS induced liver injuries (DSILI) included elevated liver enzymes, hepatitis, steatosis, cholestasis, hepatic necrosis, hepatic fibrosis, hepatic cirrhosis, veno-occlusive disease, acute liver failure requiring a liver transplant, and death. RESULTS: Over the past 50 years, approximately 21 herbs (minus germander and usnic acid that are no longer sold) and 12 dietary supplements (minus the nine no longer sold and vitamin A & niacin due to excess intake) posed a possible risk for liver injures in certain individuals. The herbs with the most number of reported publications (but not cases studies) in descending order, were germander, black cohosh, kava extract, and green tea extract. CONCLUSION: These online DS Toxic Tables will contribute to continued Phase IV post marketing surveillance to detect possible liver toxicity cases and serve to forewarn consumers, clinicians, and corporations.
Authors: Charles M Skinner; Isabelle R Miousse; Laura E Ewing; Vijayalakshmi Sridharan; Maohua Cao; Haixia Lin; D Keith Williams; Bharathi Avula; Saqlain Haider; Amar G Chittiboyina; Ikhlas A Khan; Mahmoud A ElSohly; Marjan Boerma; Bill J Gurley; Igor Koturbash Journal: Food Chem Toxicol Date: 2018-09-30 Impact factor: 6.023
Authors: Hellen A Oketch-Rabah; Amy L Roe; Cynthia V Rider; Herbert L Bonkovsky; Gabriel I Giancaspro; Victor Navarro; Mary F Paine; Joseph M Betz; Robin J Marles; Steven Casper; Bill Gurley; Scott A Jordan; Kan He; Mahendra P Kapoor; Theertham P Rao; Averell H Sherker; Robert J Fontana; Simona Rossi; Raj Vuppalanchi; Leonard B Seeff; Andrew Stolz; Jawad Ahmad; Christopher Koh; Jose Serrano; Tieraona Low Dog; Richard Ko Journal: Toxicol Rep Date: 2020-02-15
Authors: Jan Best; Stefaan Verhulst; Wing-Kin Syn; Kimberly Lagaisse; Noemi van Hul; Femke Heindryckx; Jan-Peter Sowa; Liesbeth Peeters; Hans Van Vlierberghe; Isabelle A Leclercq; Ali Canbay; Laurent Dollé; Leo A van Grunsven Journal: PLoS One Date: 2016-09-12 Impact factor: 3.240