Literature DB >> 27401570

Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to Topical Tenofovir.

Lisa M Noguchi1, Elizabeth T Montgomery2, Joseph R Biggio3, Craig W Hendrix4, Debra L Bogen5, Sharon L Hillier6, James Y Dai7, Jeanna M Piper8, Mark A Marzinke9, Charlene S Dezzutti6, S Karen Isaacs10, Jill L Schwartz11, D Heather Watts12, Richard H Beigi6.   

Abstract

Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27401570      PMCID： PMC4997886          DOI： 10.1128/AAC.00645-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

2.  Reformulated tenofovir gel for use as a dual compartment microbicide.

Authors:  Charlene S Dezzutti; Lisa C Rohan; Lin Wang; Kevin Uranker; Cory Shetler; Marilyn Cost; J D Lynam; David Friend
Journal:  J Antimicrob Chemother       Date:  2012-05-11       Impact factor: 5.790

3.  Performing Drug Safety Research During Pregnancy and Lactation: Biomedical HIV Prevention Research as a Template.

Authors:  Richard H Beigi; Lisa Noguchi; Gina Brown; Jeanna Piper; D Heather Watts
Journal:  J Womens Health (Larchmt)       Date:  2013-06-29       Impact factor: 2.681

4.  Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2.

Authors:  Sihem Benaboud; Alain Pruvost; Patrick A Coffie; Didier K Ekouévi; Saïk Urien; Elise Arrivé; Stéphane Blanche; Frédéric Théodoro; Divine Avit; François Dabis; Jean-Marc Tréluyer; Déborah Hirt
Journal:  Antimicrob Agents Chemother       Date:  2010-12-20       Impact factor: 5.191

5.  Tenofovir-based preexposure prophylaxis for HIV infection among African women.

Authors:  Jeanne M Marrazzo; Gita Ramjee; Barbra A Richardson; Kailazarid Gomez; Nyaradzo Mgodi; Gonasagrie Nair; Thesla Palanee; Clemensia Nakabiito; Ariane van der Straten; Lisa Noguchi; Craig W Hendrix; James Y Dai; Shayhana Ganesh; Baningi Mkhize; Marthinette Taljaard; Urvi M Parikh; Jeanna Piper; Benoît Mâsse; Cynthia Grossman; James Rooney; Jill L Schwartz; Heather Watts; Mark A Marzinke; Sharon L Hillier; Ian M McGowan; Z Mike Chirenje
Journal:  N Engl J Med       Date:  2015-02-05       Impact factor: 91.245

6.  Incident HIV infection in pregnant and lactating women and its effect on mother-to-child transmission in South Africa.

Authors:  Dhayendre Moodley; Tonya Esterhuizen; Logan Reddy; Pravi Moodley; Bipraj Singh; Linda Ngaleka; Devan Govender
Journal:  J Infect Dis       Date:  2011-03-11       Impact factor: 5.226

7.  A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis.

Authors:  Todd J Johnson; Meredith R Clark; Theodore H Albright; Joel S Nebeker; Anthony L Tuitupou; Justin T Clark; Judit Fabian; R Tyler McCabe; Neelima Chandra; Gustavo F Doncel; David R Friend; Patrick F Kiser
Journal:  Antimicrob Agents Chemother       Date:  2012-09-24       Impact factor: 5.191

Review 8.  Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics.

Authors:  Brian P Kearney; John F Flaherty; Jaymin Shah
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

9.  Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation.

Authors:  J C Fleishaker; N Desai; P J McNamara
Journal:  J Pharm Sci       Date:  1989-02       Impact factor: 3.534

10.  MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments.

Authors:  Craig W Hendrix; Beatrice A Chen; Vijayanand Guddera; Craig Hoesley; Jessica Justman; Clemensia Nakabiito; Robert Salata; Lydia Soto-Torres; Karen Patterson; Alexandra M Minnis; Sharavi Gandham; Kailazarid Gomez; Barbra A Richardson; Namandje N Bumpus
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240
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  4 in total

Review 1.  Where are the pregnant and breastfeeding women in new pre-exposure prophylaxis trials? The imperative to overcome the evidence gap.

Authors:  Dvora L Joseph Davey; Linda-Gail Bekker; Elizabeth A Bukusi; Benjamin H Chi; Sinead Delany-Moretlwe; Ameena Goga; Anne Drapkin Lyerly; Nyaradzo M Mgodi; Nelly Mugo; Landon Myer; Lisa M Noguchi; Lynda Stranix-Chibanda; Catherine Slack; Jillian Pintye
Journal:  Lancet HIV       Date:  2022-01-25       Impact factor: 16.070

2.  Influences on willingness to use vaginal or oral HIV PrEP during pregnancy and breastfeeding in Africa: the multisite MAMMA study.

Authors:  Ariane van der Straten; Julia H Ryan; Krishnaveni Reddy; Juliane Etima; Frank Taulo; Prisca Mutero; Jamilah Taylor; Jeanna Piper; Petina Musara
Journal:  J Int AIDS Soc       Date:  2020-06       Impact factor: 5.396

3.  After their wives have delivered, a lot of men like going out: Perceptions of HIV transmission risk and support for HIV prevention methods during breastfeeding in sub-Saharan Africa.

Authors:  Valerie L Flax; Imogen Hawley; Julia Ryan; Miria Chitukuta; Florence Mathebula; Rita Nakalega; Linly Seyama; Frank Taulo; Ariane van der Straten
Journal:  Matern Child Nutr       Date:  2020-12-15       Impact factor: 3.092

Review 4.  Are you PEPped and PrEPped for travel? Risk mitigation of HIV infection for travelers.

Authors:  D M Brett-Major; P T Scott; T A Crowell; C S Polyak; K Modjarrad; M L Robb; D L Blazes
Journal:  Trop Dis Travel Med Vaccines       Date:  2016-11-28
  4 in total

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