You-Liang Hsieh1, Marthandam Asokan Shibu2, Chong-Kuei Lii3, Vijaya Padma Viswanadha4, Yi-Lin Lin2, Chao-Hung Lai5, Yu-Feng Chen5, Kuan-Ho Lin6, Wei-Wen Kuo7, Chih-Yang Huang8. 1. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. 2. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan. 3. Department of Nutrition, China Medical University, Taichung, Taiwan. 4. Department of Biotechnology, Bharathiar University, Coimbatore, India. 5. Division of Cardiology, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung, Taiwan. 6. Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan. 7. Department of Biological Science and Technology, China Medical University, Taichung, Taiwan. 8. Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Electronic address: cyhuang@mail.cmu.edu.tw.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata (Burm. f.) Nees (Acanthaceae) has a considerable medicinal reputation in most parts of Asia as a potent medicine in the treatment of Endocrine disorders, inflammation and hypertension. AIM OF THE STUDY: Water extract of A. paniculata and its active constituent andrographolide are known to possess anti-inflammatory and anti-apoptotic effects. Our aim is to identify whether A. paniculata extract could protect myocardial damage in high-fat diet induced obese mice. MATERIALS AND METHODS: The test mice were divided into three groups fed either with normal chow or with high fat diet (obese) or with high fat diet treated with A. paniculata extract (2g/kg/day, through gavage, for a week). RESULTS: We found that the myocardial inflammation pathway related proteins were increased in the obese mouse which potentially contributes to cardiac hypertrophy and myocardial apoptosis. But feeding with A. paniculata extract showed significant inhibition on the effects of high fat diet. CONCLUSION: Our study strongly suggests that supplementation of A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obese patients.
ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata (Burm. f.) Nees (Acanthaceae) has a considerable medicinal reputation in most parts of Asia as a potent medicine in the treatment of Endocrine disorders, inflammation and hypertension. AIM OF THE STUDY: Water extract of A. paniculata and its active constituent andrographolide are known to possess anti-inflammatory and anti-apoptotic effects. Our aim is to identify whether A. paniculata extract could protect myocardial damage in high-fat diet induced obesemice. MATERIALS AND METHODS: The test mice were divided into three groups fed either with normal chow or with high fat diet (obese) or with high fat diet treated with A. paniculata extract (2g/kg/day, through gavage, for a week). RESULTS: We found that the myocardial inflammation pathway related proteins were increased in the obesemouse which potentially contributes to cardiac hypertrophy and myocardial apoptosis. But feeding with A. paniculata extract showed significant inhibition on the effects of high fat diet. CONCLUSION: Our study strongly suggests that supplementation of A. paniculata extract can be used for prevention and treatment of cardiovascular disease in obesepatients.