Literature DB >> 27399835

Synthesis of Unnatural 2-Substituted Quinolones and 1,3-Diketones by a Member of Type III Polyketide Synthases from Huperzia serrata.

Juan Wang1,2, Xiao-Hui Wang1, Xiao Liu1, Jun Li1, Xiao-Ping Shi1,2, Yue-Lin Song1, Ke-Wu Zeng3, Le Zhang1,2, Peng-Fei Tu1, She-Po Shi1.   

Abstract

A curcuminoids, benzalacetone-, and quinolone-producing type III polyketide synthase (HsPKS3) from Huperzia serrata uniquely catalyzes the formation of unnatural 2-substituted quinolones and 1,3-diketones via head-to-head condensation of two completely different substrates. The broad range of substrate tolerance of HsPKS3 facilitates accessing structurally diverse 2-substituted quinolones and 1,3-diketones.

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Year:  2016        PMID： 27399835     DOI： 10.1021/acs.orglett.6b01501

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Monitoring the Chemical Profile in Agarwood Formation within One Year and Speculating on the Biosynthesis of 2-(2-Phenylethyl)Chromones.

Authors:  Ge Liao; Wen-Hua Dong; Jin-Ling Yang; Wei Li; Jun Wang; Wen-Li Mei; Hao-Fu Dai
Journal:  Molecules       Date:  2018-05-25       Impact factor: 4.411

Review 2.  How structural subtleties lead to molecular diversity for the type III polyketide synthases.

Authors:  Hiroyuki Morita; Chin Piow Wong; Ikuro Abe
Journal:  J Biol Chem       Date:  2019-08-30       Impact factor: 5.157

3.  2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases.

Authors:  Takashi Matsui; Takeshi Kodama; Takahiro Mori; Tetsuhiro Tadakoshi; Hiroshi Noguchi; Ikuro Abe; Hiroyuki Morita
Journal:  J Biol Chem       Date:  2017-04-14       Impact factor: 5.157

4.  Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A.

Authors:  Mengquan Yang; Wenjing You; Shiwen Wu; Zhen Fan; Baofu Xu; Mulan Zhu; Xuan Li; Youli Xiao
Journal:  BMC Genomics       Date:  2017-03-22       Impact factor: 3.969

5.  Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.

Authors:  Xiao-Hui Wang; Bo-Wen Gao; Yu Nakashima; Takahiro Mori; Zhong-Xiu Zhang; Takeshi Kodama; Yuan-E Lee; Ze-Kun Zhang; Chin-Piow Wong; Qian-Qian Liu; Bo-Wen Qi; Juan Wang; Jun Li; Xiao Liu; Ikuro Abe; Hiroyuki Morita; Peng-Fei Tu; She-Po Shi
Journal:  Nat Commun       Date:  2022-01-17       Impact factor: 14.919

6.  Enzymatic synthesis of 2-hydroxy-4H-quinolizin-4-one scaffolds by integrating coenzyme a ligases and a type III PKS from Huperzia serrata.

Authors:  Juan Wang; Ning Ding; Yun Wu; Xiaoping Shi; Bowen Qi; Xiao Liu; Xiaohui Wang; Jun Li; Pengfei Tu; Shepo Shi
Journal:  RSC Adv       Date:  2020-06-22       Impact factor: 4.036
  6 in total

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