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Literature DB >> 27398286

The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?

Ruth Ann Luna¹, Tor C Savidge¹, Kent C Williams².

Abstract

The brain-gut-microbiome axis refers to the interactions between the central nervous system, gastrointestinal system, and microorganisms that live in the gastrointestinal tract. Exploring these interactions provides a rationale for why gastrointestinal disorders commonly occur in children with Autism Spectrum Disorders (ASD). Signs of altered brain-gut interactions that are closely associated with functional GI disorders (FGIDs) commonly occur in children with ASD. Studies of microbiome in ASD suggest that changes in the gut microbiome may be associated with ASD and with GI disorders in children with ASD. Further studies into the brain-gut-microbiome axis could lead to new techniques for identifying GI disorders in children with ASD and novel therapies for treating ASD behaviors.

Entities: Chemical Disease Gene Species

Keywords: ASD behaviors; Autism Spectrum Disorders, ASD; GI disorders; brain-gut axis; central nervous system; developmental disorders; functional GI disorders; gut microbiome; review

Year: 2016 PMID： 27398286 PMCID： PMC4933016 DOI： 10.1007/s40474-016-0077-7

Source DB: PubMed Journal: Curr Dev Disord Rep

43 in total

1. Functional gastrointestinal symptoms in children with anxiety disorders.

Authors: Allison M Waters; Elizabeth Schilpzand; Clare Bell; Lynn S Walker; Kari Baber
Journal: J Abnorm Child Psychol Date: 2013-01

2. Altered gut microbiota and activity in a murine model of autism spectrum disorders.

Authors: Caroline G M de Theije; Harm Wopereis; Mohamed Ramadan; Tiemen van Eijndthoven; Jolanda Lambert; Jan Knol; Johan Garssen; Aletta D Kraneveld; Raish Oozeer
Journal: Brain Behav Immun Date: 2013-12-11 Impact factor: 7.217

Review 3. Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

Authors: Bian Tiequn; Chao Guanqun; Zhang Shuo
Journal: Intern Med Date: 2015 Impact factor: 1.271

4. 1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

Authors: Sylvie Mavel; Lydie Nadal-Desbarats; Hélène Blasco; Frédérique Bonnet-Brilhault; Catherine Barthélémy; Frédéric Montigny; Pierre Sarda; Frédéric Laumonnier; Patrick Vourc'h; Christian R Andres; Patrick Emond
Journal: Talanta Date: 2013-04-09 Impact factor: 6.057

5. Pyrosequencing study of fecal microflora of autistic and control children.

Authors: Sydney M Finegold; Scot E Dowd; Viktoria Gontcharova; Chengxu Liu; Kathleen E Henley; Randall D Wolcott; Eunseog Youn; Paula H Summanen; Doreen Granpeesheh; Dennis Dixon; Minghsun Liu; Denise R Molitoris; John A Green
Journal: Anaerobe Date: 2010-07-09 Impact factor: 3.331

6. The TGR5 receptor mediates bile acid-induced itch and analgesia.

Authors: Farzad Alemi; Edwin Kwon; Daniel P Poole; TinaMarie Lieu; Victoria Lyo; Fiore Cattaruzza; Ferda Cevikbas; Martin Steinhoff; Romina Nassini; Serena Materazzi; Raquel Guerrero-Alba; Eduardo Valdez-Morales; Graeme S Cottrell; Kristina Schoonjans; Pierangelo Geppetti; Stephen J Vanner; Nigel W Bunnett; Carlos U Corvera
Journal: J Clin Invest Date: 2013-03-25 Impact factor: 14.808

7. Consumption of fermented milk product with probiotic modulates brain activity.

Authors: Kirsten Tillisch; Jennifer Labus; Lisa Kilpatrick; Zhiguo Jiang; Jean Stains; Bahar Ebrat; Denis Guyonnet; Sophie Legrain-Raspaud; Beatrice Trotin; Bruce Naliboff; Emeran A Mayer
Journal: Gastroenterology Date: 2013-03-06 Impact factor: 22.682

8. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances.

Authors: Brent L Williams; Mady Hornig; Timothy Buie; Margaret L Bauman; Myunghee Cho Paik; Ivan Wick; Ashlee Bennett; Omar Jabado; David L Hirschberg; W Ian Lipkin
Journal: PLoS One Date: 2011-09-16 Impact factor: 3.240

9. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.

Authors: Dae-Wook Kang; Jin Gyoon Park; Zehra Esra Ilhan; Garrick Wallstrom; Joshua Labaer; James B Adams; Rosa Krajmalnik-Brown
Journal: PLoS One Date: 2013-07-03 Impact factor: 3.240

10. Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder.

Authors: Lv Wang; Claus T Christophersen; Michael J Sorich; Jacobus P Gerber; Manya T Angley; Michael A Conlon
Journal: Mol Autism Date: 2013-11-04 Impact factor: 7.509

16 in total

Review 1. Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome.

Authors: Hans C Arora; Charis Eng; Daniel A Shoskes
Journal: Ann Transl Med Date: 2017-01

2. Dietary adequacy of Egyptian children with autism spectrum disorder compared to healthy developing children.

Authors: Nagwa A Meguid; Mona Anwar; Geir Bjørklund; Adel Hashish; Salvatore Chirumbolo; Maha Hemimi; Eman Sultan
Journal: Metab Brain Dis Date: 2017-01-10 Impact factor: 3.584

Review 3. Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.

Authors: Daniel W Nebert
Journal: Prog Lipid Res Date: 2017-06-09 Impact factor: 16.195

The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder?

1. Functional gastrointestinal symptoms in children with anxiety disorders.

2. Altered gut microbiota and activity in a murine model of autism spectrum disorders.

Review 3. Therapeutic effects of Lactobacillus in treating irritable bowel syndrome: a meta-analysis.

4. 1H-13C NMR-based urine metabolic profiling in autism spectrum disorders.

5. Pyrosequencing study of fecal microflora of autistic and control children.

6. The TGR5 receptor mediates bile acid-induced itch and analgesia.

7. Consumption of fermented milk product with probiotic modulates brain activity.

8. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances.

9. Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.

10. Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder.

Review 1. Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome.

2. Dietary adequacy of Egyptian children with autism spectrum disorder compared to healthy developing children.

Review 3. Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals.

Review 4. Gut feelings: the microbiota-gut-brain axis on steroids.

5. Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome.

6. Pathophysiology of Intestinal Na⁺/H⁺ exchange.

Review 7. Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.

Review 8. Implications of white matter damage in amyotrophic lateral sclerosis (Review).

Review 9. The Gut Microbiome Feelings of the Brain: A Perspective for Non-Microbiologists.

Review 10. The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders.