Literature DB >> 2739734

Mapping the transition state and pathway of protein folding by protein engineering.

A Matouschek1, J T Kellis, L Serrano, A R Fersht.   

Abstract

In the transition state for unfolding of barnase, the hydrophobic core between the major alpha-helix and beta-sheet is somewhat weakened, the C terminus of the major helix is largely intact but its N terminus is exposed and a major loop has been invaded by solvent.

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Year:  1989        PMID： 2739734     DOI： 10.1038/340122a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  206 in total

1.  Protein folding from a highly disordered denatured state: the folding pathway of chymotrypsin inhibitor 2 at atomic resolution.

Authors:  S L Kazmirski; K B Wong; S M Freund; Y J Tan; A R Fersht; V Daggett
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

2.  The major transition state in folding need not involve the immobilization of side chains.

Authors:  R A Staniforth; J L Dean; Q Zhong; E Zerovnik; A R Clarke; J P Waltho
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

3.  Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism.

Authors:  A R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

4.  From snapshot to movie: phi analysis of protein folding transition states taken one step further.

Authors:  T Ternström; U Mayor; M Akke; M Oliveberg
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

5.  A kinetically significant intermediate in the folding of barnase.

Authors:  A R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

6.  Using flexible loop mimetics to extend phi-value analysis to secondary structure interactions.

Authors:  N Ferguson; J R Pires; F Toepert; C M Johnson; Y P Pan; R Volkmer-Engert; J Schneider-Mergener; V Daggett; H Oschkinat; A Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

7.  Molecular dynamics simulations of protein folding from the transition state.

Authors:  Jörg Gsponer; Amedeo Caflisch
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

8.  Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations.

Authors:  L Li; E I Shakhnovich
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-23       Impact factor: 11.205

9.  Surfing on protein folding energy landscapes.

Authors:  Joost W H Schymkowitz; Frederic Rousseau; Luis Serrano
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-02       Impact factor: 11.205

10.  Folding a protein in a computer: an atomic description of the folding/unfolding of protein A.

Authors:  Angel E García; José N Onuchic
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205
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