| Literature DB >> 27397087 |
Jung-Ick Byun1, Soon-Tae Lee2, Jangsup Moon2, Keun-Hwa Jung2, Jun-Sang Sunwoo3, Jung-Ah Lim2, Tae-Joon Kim2, Yong-Won Shin2, Keon-Joo Lee2, Jin-Sun Jun2, Han Sang Lee2, Woo-Jin Lee2, Young-Sook Kim4, Soyun Kim4, Daejong Jeon5, Kyung-Il Park6, Ki-Young Jung2, Manho Kim2, Kon Chu7, Sang Kun Lee8.
Abstract
The aim of this study was to compare serum and cerebrospinal fluid (CSF) cytokine/chemokine levels between anti-NMDAR and anti-LGI1 encephalitis patients. Samples from fourteen anti-NMDAR encephalitis patients, ten anti-LGI1 encephalitis patients, and ten controls were analyzed for the following cytokines/chemokines: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17A, IL-23, GM-CSF, IFN-gamma, TNF-alpha, and CXCL13. Compared with controls, CSF IL-17A, IL-6 and CXCL13 were elevated in anti-NMDAR encephalitis patients (post-hoc p-values 0.002, 0.011, and 0.011, respectively) but not in anti-LGI1 encephalitis patients. In the serum, only IL-2 was increased in anti-NMDAR encephalitis. Intrathecal IL-17/IL-6 activation is a characteristic of anti-NMDAR encephalitis.Entities:
Keywords: Autoimmune encephalitis; CXCL13; Cytokine; IL-17A; IL-6; LGI1; NMDAR
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Year: 2016 PMID： 27397087 DOI： 10.1016/j.jneuroim.2016.05.023
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478