| Literature DB >> 2739671 |
S Spadari1, A Montecucco, G Pedrali-Noy, G Ciarrocchi, F Focher, U Hübscher.
Abstract
Coordinated DNA synthesis of both strands at the replication fork by a fixed 'replisome' may cause dynamic and topological problems. Based upon known properties of DNA helicase, DNA primase and DNA topoisomerases, and on novel properties of DNA polymerases and DNA ligase, we propose a 'double-loop' model for the replication of eukaryotic DNA that could minimize such problems.Mesh：
Substances：
Year: 1989 PMID： 2739671 DOI： 10.1016/0921-8734(89)90009-x
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433