PURPOSE: To compare the 12-month peripapillary retinal nerve fibre layer (pRNFL) thickness change between AD patients and normal subjects. METHODS: In this prospective case series, thirty-six patients with a diagnosis of mild to moderate AD and 36 age-matched control subjects were included. All the subjects underwent neuropsychological (MMSE, ADAS-Cog and CDR) and ophthalmological evaluation, including spectral domain optical coherence tomography (SD-OCT), at baseline and after 12 months. RESULTS: Compared with controls, AD patients had a significant reduction of the total pRNFL thickness, as well as the pRNFL thickness of the inferior and superior quadrants (p=0.04, p=0.001, and p=0.01, respectively, adjusted for baseline pRNFL measurement, age, gender, and axial length). Correlation analysis showed a significant relationship between inferior pRNFL thickness change and ADAS-Cog scores change (r=-0.35, p=0.02) as well as CDR scores at 12 months (r=-0.39, p=0.008). CONCLUSIONS: Compared with controls, AD patients had a significant reduction in pRNFL thickness over a period of 12 months. The pRNFL reduction was more prominent in the inferior quadrant and paralleled patient's cognitive decline.
PURPOSE: To compare the 12-month peripapillary retinal nerve fibre layer (pRNFL) thickness change between ADpatients and normal subjects. METHODS: In this prospective case series, thirty-six patients with a diagnosis of mild to moderate AD and 36 age-matched control subjects were included. All the subjects underwent neuropsychological (MMSE, ADAS-Cog and CDR) and ophthalmological evaluation, including spectral domain optical coherence tomography (SD-OCT), at baseline and after 12 months. RESULTS: Compared with controls, ADpatients had a significant reduction of the total pRNFL thickness, as well as the pRNFL thickness of the inferior and superior quadrants (p=0.04, p=0.001, and p=0.01, respectively, adjusted for baseline pRNFL measurement, age, gender, and axial length). Correlation analysis showed a significant relationship between inferior pRNFL thickness change and ADAS-Cog scores change (r=-0.35, p=0.02) as well as CDR scores at 12 months (r=-0.39, p=0.008). CONCLUSIONS: Compared with controls, ADpatients had a significant reduction in pRNFL thickness over a period of 12 months. The pRNFL reduction was more prominent in the inferior quadrant and paralleled patient's cognitive decline.
Authors: Victor T T Chan; Zihan Sun; Shumin Tang; Li Jia Chen; Adrian Wong; Clement C Tham; Tien Y Wong; Christopher Chen; M Kamran Ikram; Heather E Whitson; Eleonora M Lad; Vincent C T Mok; Carol Y Cheung Journal: Ophthalmology Date: 2018-08-13 Impact factor: 12.079
Authors: Lucía Jáñez-García; Omar Bachtoula; Elena Salobrar-García; Rosa de Hoz; Ana I Ramirez; Pedro Gil; José M Ramirez; Luis Jáñez-Escalada Journal: Sci Rep Date: 2021-06-03 Impact factor: 4.379
Authors: Cláudia Y Santos; Lenworth N Johnson; Stuart E Sinoff; Elena K Festa; William C Heindel; Peter J Snyder Journal: Alzheimers Dement (Amst) Date: 2018-02-07
Authors: Elena Salobrar-García; Rosa de Hoz; Ana I Ramírez; Inés López-Cuenca; Pilar Rojas; Ravi Vazirani; Carla Amarante; Raquel Yubero; Pedro Gil; María D Pinazo-Durán; Juan J Salazar; José M Ramírez Journal: PLoS One Date: 2019-08-15 Impact factor: 3.240