Fen Wu1, Yu Chen2, Ryan T Demmer3, Faruque Parvez4, Rina Rani Paul5, Ishrat Shaheen5, Golam Sarwar5, Alauddin Ahmed5, Mahbub Eunus5, Nafiz Ahsan5, Nur Mohammad Habibullah5, Tariqul Islam5, Tatjana Rundek6, Habibul Ahsan7, Moise Desvarieux8. 1. Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA. 2. Departments of Population Health and Environmental Medicine, New York University School of Medicine, New York, NY, USA. yu.chen@nyumc.org. 3. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. 4. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA. 5. U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh. 6. Departments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. 7. Department of Health Studies, Center for Cancer Epidemiology and Prevention, The University of Chicago, Chicago, IL, USA. 8. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. mdesvarieux@columbia.edu.
Abstract
AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT). RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01). CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.
AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT). RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-μm (95% CI: 2.2, 37.8) and 26.5-μm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01). CONCLUSIONS:Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.
Authors: Fen Wu; Farzana Jasmine; Muhammad G Kibriya; Mengling Liu; Oktawia Wójcik; Faruque Parvez; Ronald Rahaman; Shantanu Roy; Rachelle Paul-Brutus; Stephanie Segers; Vesna Slavkovich; Tariqul Islam; Diane Levy; Jacob L Mey; Alexander van Geen; Joseph H Graziano; Habibul Ahsan; Yu Chen Journal: Am J Epidemiol Date: 2012-04-24 Impact factor: 4.897
Authors: Kostas Kapellas; Lisa M Jamieson; Loc G Do; P Mark Bartold; Hao Wang; Louise J Maple-Brown; David Sullivan; Kerin O'Dea; Alex Brown; David S Celermajer; Gary D Slade; Michael R Skilton Journal: Int J Cardiol Date: 2014-02-22 Impact factor: 4.164
Authors: L E Chambless; G Heiss; A R Folsom; W Rosamond; M Szklo; A R Sharrett; L X Clegg Journal: Am J Epidemiol Date: 1997-09-15 Impact factor: 4.897