| Literature DB >> 27394026 |
Gowrishankar Gnanasekaran1, Rex Biedenbender2, Harley Edward Davidson3, Stefan Gravenstein4.
Abstract
Vaccine response declines with age, but currently recommended vaccines are safe and effective in reducing, if not preventing, disease altogether. Over the last decade, advancements in vaccine immunogenicity, either by increasing dose or conjugating vaccines to protein, have resulted in more immunogenic vaccines that also seem more effective in reducing clinical disease both for influenza and pneumococcus. Meanwhile, there is a resurgence in incident pertussis, exceeding prevalence from five decades ago, adding older adults to a recommended target vaccination group. This article discusses currently available vaccines, in the context of current epidemiology and recommendations, for older adults.Entities:
Keywords: Conjugate; Diphtheria; Immune senescence; Influenza; Pertussis; Pneumococcus; Tetanus; Vaccine
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Year: 2016 PMID: 27394026 DOI: 10.1016/j.cger.2016.03.001
Source DB: PubMed Journal: Clin Geriatr Med ISSN: 0749-0690 Impact factor: 3.076