M L Avila1, L R Brandão2, S Williams1, L C Ward3, M I Montoya1, J Stinson4, A Kiss5, I Lara-Corrales1, B M Feldman6. 1. Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada. 2. Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: leonardo.brandao@sickkids.ca. 3. School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Brisbane, Australia. 4. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Child Health Evaluative Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. 5. Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. 6. Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; Child Health Evaluative Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVE: Our goal was to conduct the item generation and piloting phases of a new discriminative and evaluative tool for pediatric post-thrombotic syndrome. METHODS: We followed a formative model for the development of the tool, focusing on the signs/symptoms (items) that define post-thrombotic syndrome. For item generation, pediatric thrombosis experts and subjects diagnosed with extremity post-thrombotic syndrome during childhood nominated items. In the piloting phase, items were cross-sectionally measured in children with limb deep vein thrombosis to examine item performance. RESULT: Twenty-three experts and 16 subjects listed 34 items, which were then measured in 140 subjects with previous diagnosis of limb deep vein thrombosis (70 upper extremity and 70 lower extremity). The items with strongest correlation with post-thrombotic syndrome severity and largest area under the curve were pain (in older children), paresthesia, and swollen limb for the upper extremity group, and pain (in older children), tired limb, heaviness, tightness and paresthesia for the lower extremity group. CONCLUSION: The diagnostic properties of the items and their correlations with post-thrombotic syndrome severity varied according to the assessed venous territory. The information gathered in this study will help experts decide which item should be considered for inclusion in the new tool.
OBJECTIVE: Our goal was to conduct the item generation and piloting phases of a new discriminative and evaluative tool for pediatric post-thrombotic syndrome. METHODS: We followed a formative model for the development of the tool, focusing on the signs/symptoms (items) that define post-thrombotic syndrome. For item generation, pediatric thrombosis experts and subjects diagnosed with extremity post-thrombotic syndrome during childhood nominated items. In the piloting phase, items were cross-sectionally measured in children with limb deep vein thrombosis to examine item performance. RESULT: Twenty-three experts and 16 subjects listed 34 items, which were then measured in 140 subjects with previous diagnosis of limb deep vein thrombosis (70 upper extremity and 70 lower extremity). The items with strongest correlation with post-thrombotic syndrome severity and largest area under the curve were pain (in older children), paresthesia, and swollen limb for the upper extremity group, and pain (in older children), tired limb, heaviness, tightness and paresthesia for the lower extremity group. CONCLUSION: The diagnostic properties of the items and their correlations with post-thrombotic syndrome severity varied according to the assessed venous territory. The information gathered in this study will help experts decide which item should be considered for inclusion in the new tool.
Authors: Denise Bastas; Jennifer Vincelli; Riddhita De; Eliana Benia; Sarah Gairdner; Leonardo R Brandão; Laura Avila Journal: Res Pract Thromb Haemost Date: 2022-07-29
Authors: Maria Laura Avila; Brian M Feldman; Eleanor Pullenayegum; Celeste Lumia; Madeline I Montoya; Jennifer Vincelli; Suzan Williams; Leonardo R Brandão Journal: Res Pract Thromb Haemost Date: 2019-08-28
Authors: Maria L Avila; Brian M Feldman; Suzan Williams; Leigh C Ward; Madeline I Montoya; Jennifer Stinson; Alex Kiss; Jennifer Vincelli; Celeste Lumia; Leonardo R Brandão Journal: Res Pract Thromb Haemost Date: 2018-04-17
Authors: Maria L Avila; Jennifer Stinson; Celeste Lumia; Suzan Williams; Madeline I Montoya; Brian M Feldman; Leonardo R Brandão Journal: Res Pract Thromb Haemost Date: 2018-04-15