M Adjobimey1, E Masserey2, C Adjonou1, G Gbénagnon3, V Schwoebel4, S Anagonou1, J-P Zellweger5. 1. Centre National Hospitalier de Pneumo-Phtisiologie, Cotonou, Benin. 2. Service de la Santé Publique, Vaud, Switzerland. 3. Centre Hospitalier de Pneumo-Phtisiologie Akron, Benin. 4. The International Union Against Tuberculosis and Lung Disease, Paris, France. 5. Swiss Lung Association, Berne, Switzerland.
Abstract
SETTINGS: Two large tuberculosis (TB) centres under a well-functioning National TB Programme (NTP) in Benin, West Africa. OBJECTIVE: To assess the feasibility and results of integrating a programme of isoniazid preventive therapy (IPT) in children aged <5 years exposed to TB as part of the existing routine activities of the NTP. METHOD: All children aged <5 years living in the household of a patient with smear-positive pulmonary TB were examined by a doctor and received IPT if no evidence of TB was detected. The children were followed clinically by a nurse for 6 months. RESULTS: From January 2013 to June 2014, 496 children were examined and prescribed IPT among 499 notified contacts; 86% adhered to IPT for at least 6 months. There were six deaths and three cases of active TB among the children, all during the first 3 months of follow-up. CONCLUSIONS: In an African country with moderate TB incidence and a well-functioning NTP, the integration of IPT into the NTP for children aged <5 years exposed to TB in the family was feasible based on simple tools associated with the follow-up of index cases. The rate of adherence to IPT was high.
SETTINGS: Two large tuberculosis (TB) centres under a well-functioning National TB Programme (NTP) in Benin, West Africa. OBJECTIVE: To assess the feasibility and results of integrating a programme of isoniazid preventive therapy (IPT) in children aged <5 years exposed to TB as part of the existing routine activities of the NTP. METHOD: All children aged <5 years living in the household of a patient with smear-positive pulmonary TB were examined by a doctor and received IPT if no evidence of TB was detected. The children were followed clinically by a nurse for 6 months. RESULTS: From January 2013 to June 2014, 496 children were examined and prescribed IPT among 499 notified contacts; 86% adhered to IPT for at least 6 months. There were six deaths and three cases of active TB among the children, all during the first 3 months of follow-up. CONCLUSIONS: In an African country with moderate TB incidence and a well-functioning NTP, the integration of IPT into the NTP for children aged <5 years exposed to TB in the family was feasible based on simple tools associated with the follow-up of index cases. The rate of adherence to IPT was high.
Authors: S Zawedde-Muyanja; A Nakanwagi; J P Dongo; M P Sekadde; R Nyinoburyo; G Ssentongo; A K Detjen; F Mugabe; J Nakawesi; Y Karamagi; P Amuge; A Kekitiinwa; S M Graham Journal: Int J Tuberc Lung Dis Date: 2018-11-01 Impact factor: 2.373
Authors: M Tolofoudie; A Somboro; B Diarra; Y S Sarro; H B Drame; A C G Togo; M Sanogo; A Dembele; T Togun; E Nkereuwem; B Baya; B Konate; U Egere; M Traore; M Maiga; K Saliba-Shaw; B Kampmann; S Diallo; S Doumbia; M Sylla Journal: Public Health Action Date: 2021-12-21
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