Literature DB >> 27393517

Effectiveness of crizotinib in a patient with ALK IHC-positive/FISH-negative metastatic lung adenocarcinoma.

A Rosoux1, P Pauwels2, F Duplaquet1, N D'Haene3, B Weynand4, M Delos5, R Menon6, L C Heukamp6, E Thunnissen7, S Ocak8.   

Abstract

We report a case of crizotinib effectiveness in a heavily pretreated patient with a metastatic NSCLC initially considered IHC-positive and FISH-negative for ALK rearrangement. After repeated analyses of tumor samples, borderline ALK FISH-positivity (18.5% positive cells) was demonstrated.
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  ALK; Crizotinib; Fluorescent in situ hybridization; Immunohistochemistry; Non-small-cell lung cancer

Mesh：

Substances：

Year:  2016        PMID： 27393517     DOI： 10.1016/j.lungcan.2016.06.001

Source DB:  PubMed          Journal:  Lung Cancer        ISSN： 0169-5002            Impact factor:   5.705


  4 in total

1.  Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report.

Authors:  Anna-Lena Volckmar; Volker Endris; Farastuk Bozorgmehr; Clemens Lier; Carlota Porcel; Martina Kirchner; Jonas Leichsenring; Roland Penzel; Michael Thomas; Peter Schirmacher; Arne Warth; Albrecht Stenzinger
Journal:  Diagn Pathol       Date:  2016-11-18       Impact factor: 2.644

Review 2.  ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice.

Authors:  Paul Hofman
Journal:  Cancers (Basel)       Date:  2017-08-12       Impact factor: 6.639

Review 3.  Any Place for Immunohistochemistry within the Predictive Biomarkers of Treatment in Lung Cancer Patients?

Authors:  Véronique Hofman; Sandra Lassalle; Coraline Bence; Elodie Long-Mira; Sacha Nahon-Estève; Simon Heeke; Virginie Lespinet-Fabre; Catherine Butori; Marius Ilié; Paul Hofman
Journal:  Cancers (Basel)       Date:  2018-03-13       Impact factor: 6.639

4.  RNA-based analysis of ALK fusions in non-small cell lung cancer cases showing IHC/FISH discordance.

Authors:  Claudia Vollbrecht; Dido Lenze; Michael Hummel; Annika Lehmann; Markus Moebs; Nikolaj Frost; Philipp Jurmeister; Leonille Schweizer; Udo Kellner; Manfred Dietel; Maximilian von Laffert
Journal:  BMC Cancer       Date:  2018-11-22       Impact factor: 4.430
  4 in total

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