Daniel Tiller1, Till Ittermann2, Karin H Greiser1,3, Christa Meisinger4, Carsten Agger5, Albert Hofman6, Betina Thuesen5, Allan Linneberg5,7,8, Robin Peeters5,9, Oscar Franco6, Margit Heier4, Alexander Kluttig1, Karl Werdan10, Bruno Stricker6, Sabine Schipf2, Marcello Markus2,11,12, Marcus Dörr11,12, Henry Völzke2,12, Johannes Haerting1. 1. 1 Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg , Halle (Saale), Germany . 2. 2 Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald , Greifswald, Germany . 3. 3 German Cancer Research Centre , Division of Cancer Epidemiology, Heidelberg, Germany . 4. 4 Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health , München, Germany . 5. 5 Research Centre for Prevention and Health , the Capital Region, Denmark . 6. 6 Department of Epidemiology, Department of Internal Medicine; Erasmus Medical Center , Rotterdam, The Netherlands . 7. 7 Department of Clinical Experimental Research, Rigshospitalet , Glostrup, Denmark . 8. 8 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark . 9. 9 Rotterdam Thyroid Center, Department of Internal Medicine; Erasmus Medical Center , Rotterdam, The Netherlands . 10. 10 Department of Medicine III, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany . 11. 11 Department of Internal Medicine B, University Medicine Greifswald , Greifswald, Germany . 12. 12 DZHK (German Centre for Cardiovascular Research) , partner site Greifswald, Greifswald, Germany .
Abstract
BACKGROUND: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric measurements such as waist circumference, waist-to-hip ratio, or waist-to height ratio. OBJECTIVE: This study aimed to investigate the association of thyrotropin (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population. METHOD: Data were used from four population-based longitudinal cohort studies and one population-based cross-sectional study. A total of 16,902 (8204 males) subjects aged 20-95 years from the general population were studied. Body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio were measured. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period, and study site. RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β = 0.94 cm [confidence interval (CI) 0.56-1.32]) and waist-to-height-ratio (β = 0.029 [CI 0.017-0.042]). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with a five-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH. CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers, even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately five years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.
BACKGROUND: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric measurements such as waist circumference, waist-to-hip ratio, or waist-to height ratio. OBJECTIVE: This study aimed to investigate the association of thyrotropin (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population. METHOD: Data were used from four population-based longitudinal cohort studies and one population-based cross-sectional study. A total of 16,902 (8204 males) subjects aged 20-95 years from the general population were studied. Body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio were measured. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period, and study site. RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β = 0.94 cm [confidence interval (CI) 0.56-1.32]) and waist-to-height-ratio (β = 0.029 [CI 0.017-0.042]). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with a five-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH. CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers, even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately five years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.
Authors: Till Ittermann; Marcello R P Markus; Martin Bahls; Stephan B Felix; Antje Steveling; Matthias Nauck; Henry Völzke; Marcus Dörr Journal: Sci Rep Date: 2021-05-18 Impact factor: 4.379
Authors: Agnieszka Adamska; Andrzej Raczkowski; Zofia Stachurska; Marcin Kondraciuk; Adam Jacek Krętowski; Marcin Adamski; Irina Kowalska; Karol Adam Kamiński Journal: J Clin Med Date: 2022-04-11 Impact factor: 4.964
Authors: Rasiah Thayakaran; Nicola J Adderley; Christopher Sainsbury; Barbara Torlinska; Kristien Boelaert; Dana Šumilo; Malcolm Price; G Neil Thomas; Konstantinos A Toulis; Krishnarajah Nirantharakumar Journal: BMJ Date: 2019-09-03
Authors: Maria de Fátima Haueisen Sander Diniz; Alline Maria Rezende Beleigoli; Isabela M Benseñor; Paulo A Lotufo; Alessandra C Goulart; Sandhi Maria Barreto Journal: PLoS One Date: 2020-02-07 Impact factor: 3.240