Yesenia Zapata-Masias1, Belén Marqueta2, M D Gómez Roig3, Eduardo Gonzalez-Bosquet4. 1. BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: yzapata@hsjdbcn.org. 2. BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: bmarqueta@hsjdbcn.org. 3. BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: lgomezroig@hsjdbcn.org. 4. BCNatal - Barcelona Center for Maternal Fetal and Neonatal Medicine, Hospital Sant Joan de Deu, University of Barcelona, Pg. Sant Joan de Deu, nº 2 Esplugues, 08950, Barcelona, Spain. Electronic address: edugonzalez@hsjdbcn.org.
Abstract
BACKGROUND: Evidence indicates that advanced maternal age is associated with adverse obstetric and perinatal outcomes. The purpose of this study was to evaluate pregnancy outcomes in women of advanced maternal age (≥40years). METHODS: Using a prospective study design, data were collected by the Department of Obstetrics at the San Joan de Deu Hospital of Barcelona during the 1 June 2009 to 31 May 2012 period. The results were compared across three maternal age groups (≥40 [n=654], 35-39 [n=2781], and <35 [n=7893] years). RESULTS: Of the 11328 births recorded during the study period, pregnancy-related complications were more common in women ≥40years of age. The most common disorder was diabetes (8.5% in the ≥40, 5.3% in the 35-39, and 3.0% in the <35years age groups). The women ≥40years of age also had significantly more premature births (p=0.001) and cesarean sections (17% in the ≥40, 12.5% in the 35-39, and 7.9% in the <35-year age groups; p=0.001). Intrauterine growth retardation was significantly more frequent in women aged ≥40years (17.4% in the ≥40, 15% in the 35-39, and 14.0% in the <35-year age groups; p=0.03). Fetal macrosomia was significantly more common in women ≥40years (15.4% in the ≥40, 12.6% in the 35-39, and 12% in the <35-year age groups; p=0.03). CONCLUSION: Maternal age ≥40years was associated with poorer obstetric and perinatal outcomes and increased the risks of cesarean section, intrauterine growth retardation, and fetal macrosomia.
BACKGROUND: Evidence indicates that advanced maternal age is associated with adverse obstetric and perinatal outcomes. The purpose of this study was to evaluate pregnancy outcomes in women of advanced maternal age (≥40years). METHODS: Using a prospective study design, data were collected by the Department of Obstetrics at the San Joan de Deu Hospital of Barcelona during the 1 June 2009 to 31 May 2012 period. The results were compared across three maternal age groups (≥40 [n=654], 35-39 [n=2781], and <35 [n=7893] years). RESULTS: Of the 11328 births recorded during the study period, pregnancy-related complications were more common in women ≥40years of age. The most common disorder was diabetes (8.5% in the ≥40, 5.3% in the 35-39, and 3.0% in the <35years age groups). The women ≥40years of age also had significantly more premature births (p=0.001) and cesarean sections (17% in the ≥40, 12.5% in the 35-39, and 7.9% in the <35-year age groups; p=0.001). Intrauterine growth retardation was significantly more frequent in women aged ≥40years (17.4% in the ≥40, 15% in the 35-39, and 14.0% in the <35-year age groups; p=0.03). Fetal macrosomia was significantly more common in women ≥40years (15.4% in the ≥40, 12.6% in the 35-39, and 12% in the <35-year age groups; p=0.03). CONCLUSION: Maternal age ≥40years was associated with poorer obstetric and perinatal outcomes and increased the risks of cesarean section, intrauterine growth retardation, and fetal macrosomia.
Authors: Sarah Rae Easter; Linda O Eckert; Nansi Boghossian; Rebecca Spencer; Eugene Oteng-Ntim; Christos Ioannou; Manasi Patwardhan; Margo S Harrison; Asma Khalil; Michael Gravett; Robert Goldenberg; Alastair McKelvey; Manish Gupta; Vitali Pool; Stephen C Robson; Jyoti Joshi; Sonali Kochhar; Tom McElrath Journal: Vaccine Date: 2017-12-04 Impact factor: 3.641