Literature DB >> 27389961

IL-21 and T Cell Differentiation: Consider the Context.

Yuan Tian1, Allan J Zajac2.   

Abstract

Accumulating studies demonstrate that IL-21 modulates the differentiation of various CD4 and CD8 T cell subsets and provide insights into the underlying cellular and molecular processes that are influenced by this cytokine. Intriguingly, the effects of IL-21 on T cells can be complex and vary depending on the experimental system used. We review our current understanding of the roles of IL-21 in the generation of phenotypically distinct CD4 and CD8 T cell populations and discuss the potential environmental cues, cellular factors, and molecular mediators that impact the actions of IL-21. We propose that IL-21 acts in a context-dependent manner to accentuate T cell subset development.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27389961      PMCID： PMC4969098          DOI： 10.1016/j.it.2016.06.001

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  110 in total

1.  IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells.

Authors:  Mari Strengell; Sampsa Matikainen; Jukka Sirén; Anne Lehtonen; Don Foster; Ilkka Julkunen; Timo Sareneva
Journal:  J Immunol       Date:  2003-06-01       Impact factor: 5.422

2.  STAT5 is critical to maintain effector CD8+ T cell responses.

Authors:  Pulak Tripathi; Sema Kurtulus; Sara Wojciechowski; Allyson Sholl; Kasper Hoebe; Suzanne C Morris; Fred D Finkelman; H Leighton Grimes; David A Hildeman
Journal:  J Immunol       Date:  2010-07-19       Impact factor: 5.422

3.  IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.

Authors:  Andrew P R Sutherland; Nicole Joller; Monia Michaud; Sue M Liu; Vijay K Kuchroo; Michael J Grusby
Journal:  J Immunol       Date:  2013-03-11       Impact factor: 5.422

4.  An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells.

Authors:  Weiguo Cui; Ying Liu; Jason S Weinstein; Joseph Craft; Susan M Kaech
Journal:  Immunity       Date:  2011-11-23       Impact factor: 31.745

5.  Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication.

Authors:  Suresh Pallikkuth; Kenneth Rogers; Francois Villinger; Melvin Dosterii; Monica Vaccari; Genoveffa Franchini; Rajendra Pahwa; Savita Pahwa
Journal:  Vaccine       Date:  2011-10-11       Impact factor: 3.641

6.  In vivo regulation of Bcl6 and T follicular helper cell development.

Authors:  Amanda C Poholek; Kyle Hansen; Sairy G Hernandez; Danelle Eto; Anmol Chandele; Jason S Weinstein; Xuemei Dong; Jared M Odegard; Susan M Kaech; Alexander L Dent; Shane Crotty; Joe Craft
Journal:  J Immunol       Date:  2010-06-02       Impact factor: 5.422

7.  CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death.

Authors:  Edith M Janssen; Nathalie M Droin; Edward E Lemmens; Michael J Pinkoski; Steven J Bensinger; Benjamin D Ehst; Thomas S Griffith; Douglas R Green; Stephen P Schoenberger
Journal:  Nature       Date:  2005-03-03       Impact factor: 49.962

8.  Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.

Authors:  Bruce T Schultz; Jeffrey E Teigler; Franco Pissani; Alexander F Oster; Gregory Kranias; Galit Alter; Mary Marovich; Michael A Eller; Ulf Dittmer; Merlin L Robb; Jerome H Kim; Nelson L Michael; Diane Bolton; Hendrik Streeck
Journal:  Immunity       Date:  2016-01-12       Impact factor: 31.745

9.  IL-21R signaling suppresses IL-17+ gamma delta T cell responses and production of IL-17 related cytokines in the lung at steady state and after Influenza A virus infection.

Authors:  Emily K Moser; Jie Sun; Taeg S Kim; Thomas J Braciale
Journal:  PLoS One       Date:  2015-04-07       Impact factor: 3.240

10.  B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

Authors:  Alex Karnowski; Stephane Chevrier; Gabrielle T Belz; Adele Mount; Dianne Emslie; Kathy D'Costa; David M Tarlinton; Axel Kallies; Lynn M Corcoran
Journal:  J Exp Med       Date:  2012-10-08       Impact factor: 14.307
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  46 in total

1.  Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis.

Authors:  Mia Shapiro; Bisweswar Nandi; Gabriel Gonzalez; Rao H Prabhala; Hiroshi Mashimo; Qin Huang; Natasha Y Frank; Nikhil C Munshi; Jason S Gold
Journal:  Oncoimmunology       Date:  2016-12-07       Impact factor: 8.110

2.  Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice.

Authors:  Naoto Noguchi; Risa Nakamura; Shinya Hatano; Hisakata Yamada; Xun Sun; Naoya Ohara; Yasunobu Yoshikai
Journal:  Infect Immun       Date:  2018-07-23       Impact factor: 3.441

3.  IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.

Authors:  Ho Ngai; Gengwen Tian; Amy N Courtney; Soodeh B Ravari; Linjie Guo; Bin Liu; Jingling Jin; Elise T Shen; Erica J Di Pierro; Leonid S Metelitsa
Journal:  J Immunol       Date:  2018-08-15       Impact factor: 5.422

Review 4.  CD4+ T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective.

Authors:  Laura A Vella; Ramin S Herati; E John Wherry
Journal:  Trends Mol Med       Date:  2017-11-12       Impact factor: 11.951

5.  IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.

Authors:  Rebecca A Elsner; Mark J Shlomchik
Journal:  Cell Rep       Date:  2019-11-26       Impact factor: 9.423

6.  Genotype-related variations in proinflammatory and regulatory cytokine levels in treated and treatment-naive HCV-infected patients.

Authors:  Rasoul Baharlou; Bizhan Romani; Seyed Jalal Kiani; Kaveh Sadeghi; Enayatollah Shadmand; Hadi Fazel; Farid Azizi Jalilian; Ebrahim Kord; Sajad Yaghoubi; Yousef Nikmanesh; Abbas Ahmadi Vasmehjani
Journal:  Med Microbiol Immunol       Date:  2017-11-17       Impact factor: 3.402

7.  Blockade of Treg Cell Differentiation and Function by the Interleukin-21-Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus.

Authors:  Hiroshi Kato; Andras Perl
Journal:  Arthritis Rheumatol       Date:  2018-01-30       Impact factor: 10.995

8.  IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis.

Authors:  Catherine H Poholek; Sarah J Dulson; Allan J Zajac; Laurie E Harrington
Journal:  Immunohorizons       Date:  2019-06-04

9.  Complex and Multilayered Role of IL-21 Signaling during Thymic Development.

Authors:  Magali M Moretto; SuJin Hwang; Keer Chen; Imtiaz A Khan
Journal:  J Immunol       Date:  2019-07-24       Impact factor: 5.422

Review 10.  Using two phases of the CD4 T cell response to blood-stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium falciparum infection.

Authors:  Komi Gbedande; Victor H Carpio; Robin Stephens
Journal:  Immunol Rev       Date:  2020-01       Impact factor: 12.988
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