Valérie Briand1, Jessica Saal1, Caline Ghafari1, Bich-Tram Huynh1, Nadine Fievet1, Christentze Schmiegelow2, Achille Massougbodji3, Philippe Deloron1, Jennifer Zeitlin4, Michel Cot1. 1. Mère et enfant face aux infections tropicales (UMR216), Institut de Recherche pour le Développement Faculté de Pharmacie, Université Paris Descartes, COMUE Sorbonne Paris Cité 2. Center for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Denmark. 3. Laboratoire de parasitologie, Faculté des Sciences de la Santé Centre d'Étude et de Recherche sur le Paludisme Associé à la Grossesse et l'Enfance, Cotonou, Benin. 4. Faculté de Pharmacie, Université Paris Descartes, COMUE Sorbonne Paris Cité Obstetrical, Perinatal, and Pediatric Epidemiology Research Team, Center for Epidemiology and Biostatistics (U1153), Institut national de la santé et de la recherche médicale, Paris, France.
Abstract
BACKGROUND: Few studies have evaluated the effect of malaria on intrauterine growth restriction on the basis of the fetal growth rate, rather than just the small-for-gestational age z score. Here, we assessed the impact of malaria on IUGR, using data from a longitudinal, ultrasonography-based follow-up study of Beninese women. METHODS: A total of 1016 women were followed up from gestational week 17 to delivery. Malaria was detected every month. Women underwent ultrasonography 4 times for gestational age determination and fetal biometry. We assessed the effect of malaria on birth weight-for-gestational age z score (n = 735 women) and fetal growth velocity (n = 664), defined as a change in fetal weight z score over time. RESULTS: Malaria was detected in 43% of women. Fetal growth velocity was negative overall, decreasing further at the end of the third trimester. Women with ≥2 malarial parasite infections tended to have lower z scores than uninfected women. Malaria both in early and late pregnancy was associated with a reduction in fetal growth velocity, which occurred either immediately or with a delay after infection. DISCUSSIONS: We confirmed the deleterious effect of malaria during both early and late pregnancy on fetal growth. This stresses the importance of starting preventive measures against malaria as early as possible during pregnancy.
BACKGROUND: Few studies have evaluated the effect of malaria on intrauterine growth restriction on the basis of the fetal growth rate, rather than just the small-for-gestational age z score. Here, we assessed the impact of malaria on IUGR, using data from a longitudinal, ultrasonography-based follow-up study of Beninese women. METHODS: A total of 1016 women were followed up from gestational week 17 to delivery. Malaria was detected every month. Women underwent ultrasonography 4 times for gestational age determination and fetal biometry. We assessed the effect of malaria on birth weight-for-gestational age z score (n = 735 women) and fetal growth velocity (n = 664), defined as a change in fetal weight z score over time. RESULTS:Malaria was detected in 43% of women. Fetal growth velocity was negative overall, decreasing further at the end of the third trimester. Women with ≥2 malarial parasite infections tended to have lower z scores than uninfected women. Malaria both in early and late pregnancy was associated with a reduction in fetal growth velocity, which occurred either immediately or with a delay after infection. DISCUSSIONS: We confirmed the deleterious effect of malaria during both early and late pregnancy on fetal growth. This stresses the importance of starting preventive measures against malaria as early as possible during pregnancy.
Authors: Jordan E Cates; Holger W Unger; Valerie Briand; Nadine Fievet; Innocent Valea; Halidou Tinto; Umberto D'Alessandro; Sarah H Landis; Seth Adu-Afarwuah; Kathryn G Dewey; Feiko O Ter Kuile; Meghna Desai; Stephanie Dellicour; Peter Ouma; Julie Gutman; Martina Oneko; Laurence Slutsker; Dianne J Terlouw; Simon Kariuki; John Ayisi; Mwayiwawo Madanitsa; Victor Mwapasa; Per Ashorn; Kenneth Maleta; Ivo Mueller; Danielle Stanisic; Christentze Schmiegelow; John P A Lusingu; Anna Maria van Eijk; Melissa Bauserman; Linda Adair; Stephen R Cole; Daniel Westreich; Steven Meshnick; Stephen Rogerson Journal: PLoS Med Date: 2017-08-08 Impact factor: 11.069
Authors: Erin E Tran; Morgan L Cheeks; Abel Kakuru; Mary K Muhindo; Paul Natureeba; Miriam Nakalembe; John Ategeka; Patience Nayebare; Moses Kamya; Diane Havlir; Margaret E Feeney; Grant Dorsey; Stephanie L Gaw Journal: Malar J Date: 2020-06-24 Impact factor: 2.979
Authors: Makoto Saito; Rashid Mansoor; Kalynn Kennon; Anupkumar R Anvikar; Elizabeth A Ashley; Daniel Chandramohan; Lauren M Cohee; Umberto D'Alessandro; Blaise Genton; Mary Ellen Gilder; Elizabeth Juma; Linda Kalilani-Phiri; Irene Kuepfer; Miriam K Laufer; Khin Maung Lwin; Steven R Meshnick; Dominic Mosha; Atis Muehlenbachs; Victor Mwapasa; Norah Mwebaza; Michael Nambozi; Jean-Louis A Ndiaye; François Nosten; Myaing Nyunt; Bernhards Ogutu; Sunil Parikh; Moo Kho Paw; Aung Pyae Phyo; Mupawjay Pimanpanarak; Patrice Piola; Marcus J Rijken; Kanlaya Sriprawat; Harry K Tagbor; Joel Tarning; Halidou Tinto; Innocent Valéa; Neena Valecha; Nicholas J White; Jacher Wiladphaingern; Kasia Stepniewska; Rose McGready; Philippe J Guérin Journal: BMC Med Date: 2020-06-02 Impact factor: 8.775
Authors: Kira L Newman; Kathryn Gustafson; Janet A Englund; Amalia Magaret; Subarna Khatry; Steven C LeClerq; James M Tielsch; Joanne Katz; Helen Y Chu Journal: Open Forum Infect Dis Date: 2019-01-14 Impact factor: 3.835