Umit Yolcu1, Eylem Çağıltay2, Sami Toyran3, Fahrettin Akay3, Salih Uzun4, Fatih C Gundogan5. 1. a Department of Ophthalmology , Mevki Military Hospital , Ankara , Turkey. 2. b Department of Endocrinology , Izmir Military Hospital , Izmir , Turkey. 3. c Department of Ophthalmology , Izmir Military Hospital , Izmir , Turkey. 4. d Department of Ophthalmology , Etimesgut Military Hospital , Ankara , Turkey. 5. e Department of Ophthalmology , GATA Medical School , Ankara , Turkey.
Abstract
OBJECTIVES: To explore choroidal thickness (ChT) and retinal thickness (RT) changes in patients with type 1 diabetes mellitus (DM). METHODS: Sixty patients with Type 1 DM and 60 age- and sex-matched healthy controls were included in this prospective case-control clinical study. All patients underwent a complete ophthalmological examination. ChT of each participant was measured at the fovea and horizontal nasal and temporal quadrants at 500-µm intervals to 1500 µm from the foveola using spectral-domain optical coherence tomography (SD-OCT). Age, gender, disease duration, serum glycosylated hemoglobin (HbA1c), fasting glucose level, axial length (AL) and refractive error were noted and analyzed. RESULTS: Mean disease duration, mean HbA1c and mean fasting blood glucose in diabetic patients were 6.1±2.8 years, (8.9±0.9)% and 287.5±69.1 mg/dl, respectively. Age, gender, AL, spherical equivalent differences between the patients and subjects were insignificant (p>0.05). Subfoveal ChT, nasal quadrant ChT measurements, temporal 1500 µm and mean nasal ChT were significantly lower in diabetic patients (p<0.05 for all). Temporal 500 µm and 1000 µm ChT measurements, mean temporal ChT, average ChT, central macular thickness and average macular thickness did not differ significantly between the groups (p>0.05 for all). CONCLUSION: This study showed that there is choroidal thinning in young Type 1 diabetic patients with early period of disease duration without diabetic retinopathy nor any other systemic diseases. Choroidal changes in type 1 DM seem to begin at nasal and distal temporal retina. These results need to be verified by larger and longitudinal studies.
OBJECTIVES: To explore choroidal thickness (ChT) and retinal thickness (RT) changes in patients with type 1 diabetes mellitus (DM). METHODS: Sixty patients with Type 1 DM and 60 age- and sex-matched healthy controls were included in this prospective case-control clinical study. All patients underwent a complete ophthalmological examination. ChT of each participant was measured at the fovea and horizontal nasal and temporal quadrants at 500-µm intervals to 1500 µm from the foveola using spectral-domain optical coherence tomography (SD-OCT). Age, gender, disease duration, serum glycosylated hemoglobin (HbA1c), fasting glucose level, axial length (AL) and refractive error were noted and analyzed. RESULTS: Mean disease duration, mean HbA1c and mean fasting blood glucose in diabeticpatients were 6.1±2.8 years, (8.9±0.9)% and 287.5±69.1 mg/dl, respectively. Age, gender, AL, spherical equivalent differences between the patients and subjects were insignificant (p>0.05). Subfoveal ChT, nasal quadrant ChT measurements, temporal 1500 µm and mean nasal ChT were significantly lower in diabeticpatients (p<0.05 for all). Temporal 500 µm and 1000 µm ChT measurements, mean temporal ChT, average ChT, central macular thickness and average macular thickness did not differ significantly between the groups (p>0.05 for all). CONCLUSION: This study showed that there is choroidal thinning in young Type 1 diabeticpatients with early period of disease duration without diabetic retinopathy nor any other systemic diseases. Choroidal changes in type 1 DM seem to begin at nasal and distal temporal retina. These results need to be verified by larger and longitudinal studies.
Authors: Joanna Gołębiewska; Andrzej Olechowski; Marta Wysocka-Mincewicz; Marta Baszyńska-Wilk; Artur Groszek; Agnieszka Czeszyk-Piotrowicz; Mieczysław Szalecki; Wojciech Hautz Journal: J Diabetes Res Date: 2018-04-03 Impact factor: 4.011