| Literature DB >> 2738886 |
E C Taylor1, J M Hamby, C Shih, G B Grindey, S M Rinzel, G P Beardsley, R G Moran.
Abstract
Syntheses of 5-deaza-5,6,7,8-tetrahydrofolic acid (7a) and its 10-formyl (7b), 10-acetyl (7c), and 10-methyl (7d) derivatives are described. These compounds, prepared as analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), the lead compound of a new class of folate antimetabolites, exhibit potent growth inhibition against leukemic cells in culture as well as substantial antitumor activity against transplantable murine solid tumors in vivo.Entities:
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Year: 1989 PMID： 2738886 DOI： 10.1021/jm00127a019
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446