| Literature DB >> 27388630 |
L B Korolevskaya1,2, K V Shmagel3,4, E V Saidakova3,4, N G Shmagel3,5, S V Slobodchikova3,4, V A Chereshnev3,6,7.
Abstract
We studied the effect of hepatitis C virus coinfection on T cell subpopulations in HIV-infected patients receiving antiretroviral therapy. Coinfection with hepatitis C virus was followed by a decrease in the number of naive CD4(+) T cells and an increase in the count of central CD8(+) memory T cells in these patients. Hepatitis C virus had no effect on the number of CD4(+) memory T cells (main target for HIV). This can explain the absence of strong negative effect of hepatitis C virus on the course of HIV infection.Entities:
Keywords: HCV coinfection; HIV infection; T cell subpopulations; antiretroviral therapy
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Year: 2016 PMID： 27388630 DOI： 10.1007/s10517-016-3395-1
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804