Literature DB >> 27388572

Increased mortality among people with anxiety disorders: total population study.

Sandra M Meier1, Manuel Mattheisen2, Ole Mors2, Preben B Mortensen2, Thomas M Laursen2, Brenda W Penninx2.   

Abstract

BACKGROUND: Anxiety disorders and depression are the most common mental disorders worldwide and have a striking impact on global disease burden. Although depression has consistently been found to increase mortality; the role of anxiety disorders in predicting mortality risk is unclear. AIMS: To assess mortality risk in people with anxiety disorders.
METHOD: We used nationwide Danish register data to conduct a prospective cohort study with over 30 million person-years of follow-up.
RESULTS: In total, 1066 (2.1%) people with anxiety disorders died during an average follow-up of 9.7 years. The risk of death by natural and unnatural causes was significantly higher among individuals with anxiety disorders (natural mortality rate ratio (MRR) = 1.39, 95% CI 1.28-1.51; unnatural MRR = 2.46, 95% CI 2.20-2.73) compared with the general population. Of those who died from unnatural causes, 16.5% had comorbid diagnoses of depression (MRR = 11.72, 95% CI 10.11-13.51).
CONCLUSIONS: Anxiety disorders significantly increased mortality risk. Comorbidity of anxiety disorders and depression played an important part in the increased mortality. © The Royal College of Psychiatrists 2016.

Entities:  

Mesh：

Year:  2016        PMID： 27388572      PMCID： PMC5082973          DOI： 10.1192/bjp.bp.115.171975

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


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