Xiaolong Ge1, Hongliang Tian1, Chao Ding1, Lili Gu1, Yao Wei1, Jianfeng Gong2, Weiming Zhu1, Ning Li3, Jieshou Li1. 1. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. 2. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: jinlingh_gongjf@163.com. 3. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address: jinlingh_lining@163.com.
Abstract
BACKGROUND AND AIMS: Intestinal microbiota and soluble dietary fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with fiber for slow transit constipation (STC). METHODS: We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive soluble dietary fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. RESULTS: At the study end, clinical improvement and remission of constipated patients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p <0.05) and an improved stool consistency after FMT combined with fiber. When compared to pre-treatment, PAC-SYM scores improved significantly from 2.0 ± 0.4 to 1.5 ± 0.6 after treatment (p <0.05). Meanwhile, patients showed an acceleration of colonic transit time from 81.9 ± 9.5 to 53.5 ± 11.2 h at week 12. During follow-up, patients felt satisfied with improved GIQLI. No serious adverse events were observed. CONCLUSION: This is a pilot study confirming that FMT combined with fiber may improve symptoms experienced by constipated patients by regulating intestinal microecology, without any serious adverse events.
BACKGROUND AND AIMS: Intestinal microbiota and soluble dietary fiber play an important role in intestinal microecology, which is closely related to gut motility. Regulating intestinal microecology comprised of fecal microbiota transplantation (FMT) or fiber supplementation is becoming a novel therapy for functional gastrointestinal disease. We launched this study to evaluate the efficacy and safety of FMT combined with fiber for slow transit constipation (STC). METHODS: We performed a study of 21 patients with STC. Participants received FMT (via nasojejunal tubes) on 3 consecutive days. After FMT, they were recommended to receive soluble dietary fiber for 4 weeks (8 g, twice daily). Rate of clinical improvement and remission, constipation-related symptoms (PAC-SYM scores), bowel movements per week, colonic transit time (CTT) and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. RESULTS: At the study end, clinical improvement and remission of constipatedpatients reached 66.7 and 42.9%, respectively. The patients showed an increased stool frequency from 1.7 ± 0.5 per week to 4.8 ± 2.1 per week (p <0.05) and an improved stool consistency after FMT combined with fiber. When compared to pre-treatment, PAC-SYM scores improved significantly from 2.0 ± 0.4 to 1.5 ± 0.6 after treatment (p <0.05). Meanwhile, patients showed an acceleration of colonic transit time from 81.9 ± 9.5 to 53.5 ± 11.2 h at week 12. During follow-up, patients felt satisfied with improved GIQLI. No serious adverse events were observed. CONCLUSION: This is a pilot study confirming that FMT combined with fiber may improve symptoms experienced by constipatedpatients by regulating intestinal microecology, without any serious adverse events.
Authors: Annabel K Clancy; Christina Lee; Harrison Hamblin; Anoja W Gunaratne; Antoinette LeBusque; Eleanor J Beck; Marie V Dawson; Thomas J Borody Journal: Nutrients Date: 2021-04-28 Impact factor: 5.717
Authors: David Avelar Rodriguez; Jelena Popov; Elyanne M Ratcliffe; Erick Manuel Toro Monjaraz Journal: Front Pediatr Date: 2021-01-20 Impact factor: 3.418