| Literature DB >> 27386872 |
Chung Sub Kim1, Won Se Suh1, Lalita Subedi2,3, Sun Yeou Kim2,3, Sang Un Choi4, Kang Ro Lee5.
Abstract
Phytochemical investigation of the bark from the stems of Sorbus commixta led to the isolation and characterization of a new fatty acid, sorcomic acid (1), along with nine known analogues (2-10). The structure of the new compound (1) was determined through NMR ((1)H and (13)C NMR, HSQC, HMBC, and NOESY), MS, and specific optical rotation. The known compounds (2-10) were identified by comparison of their spectroscopic data with those in the literature. The biological activities of all the isolated compounds (1-10) were evaluated: compounds 1, 5, and 7 potently induced NGF secretion from C6 glioma cells (233.40 ± 12.82, 194.40 ± 8.05, and 185.74 ± 10.25 %, respectively) and compound 10 reduced NO levels with an IC50 value of 71.25 μM in murine microglia BV2 cells stimulated by LPS.Entities:
Keywords: Anti-neuroinflammation; Fatty acids; Neuroprotection; Rosaceae; Sorbus commixta
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Year: 2016 PMID： 27386872 DOI： 10.1007/s11745-016-4172-7
Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880