Literature DB >> 27385176

Effect of Disease Pathologies on Transporter Expression and Function.

Amandla Atilano-Roque1, Gavriel Roda1, Uma Fogueri1, Jennifer J Kiser1, Melanie S Joy1,2.   

Abstract

Transporters are important determinants of drug absorption, distribution, and excretion. The clinical relevance of drug transporters in drug disposition and toxicology depends on their localization in liver, kidney, and brain. There has been growing evidence regarding the importance of disease status on alterations in metabolizing enzymes and transporter proteins. This review focuses on uptake and efflux transporter proteins in liver, kidney, and brain and discusses mechanisms of altered transporter expression and function secondary to disease.
© 2016, The American College of Clinical Pharmacology.

Keywords:  brain; kidney disease; liver disease; transporters

Mesh：

Substances：

Year:  2016        PMID： 27385176     DOI： 10.1002/jcph.768

Source DB:  PubMed          Journal:  J Clin Pharmacol        ISSN： 0091-2700            Impact factor:   3.126


  11 in total

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Review 3.  Pharmacology of Antiretrovirals in the Female Genital Tract for HIV Prevention.

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Review 4.  Recent advances in understanding hepatic drug transport.

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Authors:  Lindsey H M Te Brake; Vycke Yunivita; Resvi Livia; Nanny Soetedjo; Eleonora van Ewijk-Beneken Kolmer; Jan B Koenderink; David M Burger; Prayudi Santoso; Reinout van Crevel; Bachti Alisjahbana; Rob E Aarnoutse; Rovina Ruslami
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8.  Protein Abundance of Clinically Relevant Drug Transporters in The Human Kidneys.

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Review 9.  Extrahepatic Drug Transporters in Liver Failure: Focus on Kidney and Gastrointestinal Tract.

Authors:  Marek Droździk; Stefan Oswald; Agnieszka Droździk
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10.  Modeling alcohol-associated liver disease in a human Liver-Chip.

Authors:  Janna C Nawroth; Debora B Petropolis; Dimitris V Manatakis; Tengku Ibrahim Maulana; Gabriel Burchett; Katharina Schlünder; Anke Witt; Abhishek Shukla; Konstantia Kodella; Janey Ronxhi; Gauri Kulkarni; Geraldine Hamilton; Ekihiro Seki; Shelly Lu; Katia C Karalis
Journal:  Cell Rep       Date:  2021-07-20       Impact factor: 9.423
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