OBJECTIVE: Rickettsia conorii is responsible for the Mediterranean Spotted Fever. Recently, new rickettsial species have been recognized in Europe and implicated in human diseases. Clinical features often differ greatly from each other, but non-severe liver involvement is frequently observed during any rickettsial infection. CASE REPORT: We describe the unique case of a patient presented with significant high aminotransferase levels due to the first human R. aeschlimannii infection ever detected in Italy. The hypothesis of rickettsiosis was made on the basis of a comprehensive medical history and was confirmed by serological tests. Molecular analyses made on a sample of hepatic tissue revealed the presence of a rickettsial species never found before in human liver. CONCLUSIONS: A brief review of the literature is reported to highlight how relevant this case is and to remind that rickettsioses should be in the differential diagnoses of acute hepatitis, considering mostly the recent spread of new rickettsial species.
OBJECTIVE:Rickettsia conorii is responsible for the Mediterranean Spotted Fever. Recently, new rickettsial species have been recognized in Europe and implicated in human diseases. Clinical features often differ greatly from each other, but non-severe liver involvement is frequently observed during any rickettsial infection. CASE REPORT: We describe the unique case of a patient presented with significant high aminotransferase levels due to the first humanR. aeschlimanniiinfection ever detected in Italy. The hypothesis of rickettsiosis was made on the basis of a comprehensive medical history and was confirmed by serological tests. Molecular analyses made on a sample of hepatic tissue revealed the presence of a rickettsial species never found before in human liver. CONCLUSIONS: A brief review of the literature is reported to highlight how relevant this case is and to remind that rickettsioses should be in the differential diagnoses of acute hepatitis, considering mostly the recent spread of new rickettsial species.
Authors: Antonella Tinelli; Maria Pia Santacroce; Giuseppe Passantino; Rosa Patruno; Salvatore Desantis; Rosa Leone; Paola Gorgoni; Nicola Zizzo Journal: Environ Sci Pollut Res Int Date: 2019-12-09 Impact factor: 4.223
Authors: Tove Hoffman; Andreas Sjödin; Caroline Öhrman; Linda Karlsson; Ryelan Francis McDonough; Jason W Sahl; Dawn Birdsell; David M Wagner; Laura G Carra; Peter Wilhelmsson; John H-O Pettersson; Christos Barboutis; Jordi Figuerola; Alejandro Onrubia; Yosef Kiat; Dario Piacentini; Thomas G T Jaenson; Per-Eric Lindgren; Sara Moutailler; Thord Fransson; Mats Forsman; Kenneth Nilsson; Åke Lundkvist; Björn Olsen Journal: Microorganisms Date: 2022-07-11