| Literature DB >> 27383164 |
V A Shibnev1, T M Garaev2, P G Deryabin1, M P Finogenova1, A G Botikov1, D V Mishin1.
Abstract
New amino acid derivatives with carbocycles of adamantine and quinaldic acid were synthesized and their in vitro antiviral activity against influenza A/H5N1 virus was evaluated. Experiments on cultured embryonic porcine kidney epithelial cells showed that amino acid derivatives suppressed viral replication. Tret-butyloxycarbonyl-DL-methionylsulfonyl-1-adamantayl ethylamine and benzyloxycarbonyl-L-trypthophanyl-1-adamantayl ethylamine compounds demonstrated high activity in all in vitro experiments. Moreover, some compounds showed virucidal activity against influenza A/H5N1 virus.Entities:
Keywords: adamantane derivatives; amino acids; antiviral activity; influenza A/H5N1 virus; remantadine
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Year: 2016 PMID： 27383164 DOI： 10.1007/s10517-016-3396-0
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804