Literature DB >> 27382154

Modeling confounding by half-sibling regression.

Bernhard Schölkopf1, David W Hogg2, Dun Wang2, Daniel Foreman-Mackey2, Dominik Janzing3, Carl-Johann Simon-Gabriel3, Jonas Peters3.   

Abstract

We describe a method for removing the effect of confounders to reconstruct a latent quantity of interest. The method, referred to as "half-sibling regression," is inspired by recent work in causal inference using additive noise models. We provide a theoretical justification, discussing both independent and identically distributed as well as time series data, respectively, and illustrate the potential of the method in a challenging astronomy application.

Keywords:  astronomy; causal inference; exoplanet detection; machine learning; systematic error modeling

Year:  2016        PMID: 27382154      PMCID: PMC4941423          DOI: 10.1073/pnas.1511656113

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  6 in total

1.  Using control genes to correct for unwanted variation in microarray data.

Authors:  Johann A Gagnon-Bartsch; Terence P Speed
Journal:  Biostatistics       Date:  2011-11-17       Impact factor: 5.899

2.  A unified mixed-model method for association mapping that accounts for multiple levels of relatedness.

Authors:  Jianming Yu; Gael Pressoir; William H Briggs; Irie Vroh Bi; Masanori Yamasaki; John F Doebley; Michael D McMullen; Brandon S Gaut; Dahlia M Nielsen; James B Holland; Stephen Kresovich; Edward S Buckler
Journal:  Nat Genet       Date:  2005-12-25       Impact factor: 38.330

3.  Adjusting batch effects in microarray expression data using empirical Bayes methods.

Authors:  W Evan Johnson; Cheng Li; Ariel Rabinovic
Journal:  Biostatistics       Date:  2006-04-21       Impact factor: 5.899

4.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

5.  Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots.

Authors:  Hyun Min Kang; Chun Ye; Eleazar Eskin
Journal:  Genetics       Date:  2008-09-14       Impact factor: 4.562

6.  Correcting gene expression data when neither the unwanted variation nor the factor of interest are observed.

Authors:  Laurent Jacob; Johann A Gagnon-Bartsch; Terence P Speed
Journal:  Biostatistics       Date:  2015-08-17       Impact factor: 5.899

  6 in total
  3 in total

1.  Drawing causal inference from Big Data.

Authors:  Richard M Shiffrin
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-05       Impact factor: 11.205

2.  AC-PCoA: Adjustment for confounding factors using principal coordinate analysis.

Authors:  Yu Wang; Fengzhu Sun; Wei Lin; Shuqin Zhang
Journal:  PLoS Comput Biol       Date:  2022-07-13       Impact factor: 4.779

3.  CoCoA-diff: counterfactual inference for single-cell gene expression analysis.

Authors:  Yongjin P Park; Manolis Kellis
Journal:  Genome Biol       Date:  2021-08-17       Impact factor: 13.583

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.