| Literature DB >> 27381718 |
Krzysztof Rakus1, Maygane Ronsmans2, Alain Vanderplasschen3.
Abstract
Fever is an evolutionary conserved defense mechanism which is present in both endothermic and ectothermic vertebrates. Ectotherms in response to infection can increase their body temperature by moving to warmer places. This process is known as behavioral fever. In this review, we summarize the current knowledge on the mechanisms of induction of fever in mammals. We further discuss the evolutionary conserved mechanisms existing between fever of mammals and behavioral fever of ectothermic vertebrates. Finally, the experimental evidences supporting an adaptive value of behavioral fever expressed by ectothermic vertebrates are summarized.Entities:
Keywords: Behavioral fever; Ectotherms; Fever; Innate immunity; Prostaglandins; Pyrogens
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Year: 2016 PMID: 27381718 DOI: 10.1016/j.dci.2016.06.027
Source DB: PubMed Journal: Dev Comp Immunol ISSN: 0145-305X Impact factor: 3.636