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Literature DB >> 27381463

Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways.

Abstract

G protein-coupled receptors (GPCRs) regulate virtually all metabolic processes, including glucose and energy homeostasis. Recently, the use of designer GPCRs referred to as designer receptors exclusively activated by designer drug (DREADDs) has made it possible to dissect metabolically relevant GPCR signaling pathways in a temporally and spatially controlled fashion in vivo. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Keywords: DREADD; G protein-coupled receptor; designer GPCR; diabetes; metabolism; obesity

Mesh：

Substances：

Year: 2016 PMID： 27381463 PMCID： PMC4992635 DOI： 10.1016/j.tem.2016.04.001

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

14 in total

1. A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways.

Authors: Jianxin Hu; Matthew Stern; Luis E Gimenez; Lizzy Wanka; Lu Zhu; Mario Rossi; Jaroslawna Meister; Asuka Inoue; Annette G Beck-Sickinger; Vsevolod V Gurevich; Jürgen Wess
Journal: J Biol Chem Date: 2016-02-05 Impact factor: 5.157

Review 2. G protein-coupled receptors as targets for anti-diabetic therapeutics.

Authors: Da Young Oh; Jerrold M Olefsky
Journal: Nat Rev Drug Discov Date: 2016-01-29 Impact factor: 84.694

3. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

Authors: Blaine N Armbruster; Xiang Li; Mark H Pausch; Stefan Herlitze; Bryan L Roth
Journal: Proc Natl Acad Sci U S A Date: 2007-03-02 Impact factor: 11.205

Review 4. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Authors: Daniel J Urban; Bryan L Roth
Journal: Annu Rev Pharmacol Toxicol Date: 2014-09-25 Impact factor: 13.820

5. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

Authors: Michael J Krashes; Shuichi Koda; ChianPing Ye; Sarah C Rogan; Andrew C Adams; Daniel S Cusher; Eleftheria Maratos-Flier; Bryan L Roth; Bradford B Lowell
Journal: J Clin Invest Date: 2011-04 Impact factor: 14.808

6. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP.

Authors: Michael J Krashes; Bhavik P Shah; Shuichi Koda; Bradford B Lowell
Journal: Cell Metab Date: 2013-10-01 Impact factor: 27.287

7. A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.

Authors: Jian Hua Li; Shalini Jain; Sara M McMillin; Yinghong Cui; Dinesh Gautam; Wataru Sakamoto; Huiyan Lu; William Jou; Owen P McGuinness; Oksana Gavrilova; Jürgen Wess
Journal: Endocrinology Date: 2013-07-16 Impact factor: 4.736

8. A chemical-genetic approach to study G protein regulation of beta cell function in vivo.

Authors: Jean-Marc Guettier; Dinesh Gautam; Marco Scarselli; Inigo Ruiz de Azua; Jian Hua Li; Erica Rosemond; Xiaochao Ma; Frank J Gonzalez; Blaine N Armbruster; Huiyan Lu; Bryan L Roth; Jürgen Wess
Journal: Proc Natl Acad Sci U S A Date: 2009-10-26 Impact factor: 11.205

Review 9. DREADDs for Neuroscientists.

Authors: Bryan L Roth
Journal: Neuron Date: 2016-02-17 Impact factor: 17.173

10. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Authors: Ken-ichiro Nakajima; Zhenzhong Cui; Chia Li; Jaroslawna Meister; Yinghong Cui; Ou Fu; Adam S Smith; Shalini Jain; Bradford B Lowell; Michael J Krashes; Jürgen Wess
Journal: Nat Commun Date: 2016-01-08 Impact factor: 14.919

9 in total

1. Skeletal Muscle-Specific Activation of G_q Signaling Maintains Glucose Homeostasis.

Authors: Derek B J Bone; Jaroslawna Meister; Jonas R Knudsen; Diptadip Dattaroy; Amanda Cohen; Regina Lee; Huiyan Lu; Daniel Metzger; Thomas E Jensen; Jürgen Wess
Journal: Diabetes Date: 2019-04-01 Impact factor: 9.461

Review 2. Remote control of glucose-sensing neurons to analyze glucose metabolism.

Authors: Alexandra Alvarsson; Sarah A Stanley
Journal: Am J Physiol Endocrinol Metab Date: 2018-05-29 Impact factor: 4.310

3. Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle.

Authors: Jonas R Knudsen; Kaspar W Persson; Jaroslawna Meister; Christian S Carl; Steffen H Raun; Nicoline R Andersen; Lykke Sylow; Bente Kiens; Thomas E Jensen; Erik A Richter; Maximilian Kleinert
Journal: Am J Physiol Endocrinol Metab Date: 2021-12-06 Impact factor: 4.310

4. Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells.

Authors: John T Walker; Rachana Haliyur; Heather A Nelson; Matthew Ishahak; Gregory Poffenberger; Radhika Aramandla; Conrad Reihsmann; Joseph R Luchsinger; Diane C Saunders; Peng Wang; Adolfo Garcia-Ocaña; Rita Bottino; Ashutosh Agarwal; Alvin C Powers; Marcela Brissova
Journal: JCI Insight Date: 2020-05-21