| Literature DB >> 27381361 |
Sarah A Cronin1, Aarón Gutiérrez Collar, Sivaji Gundala, Claudio Cornaggia, Esther Torrente, Francesco Manoni, Astrid Botte, Brendan Twamley, Stephen J Connon.
Abstract
The first catalytic, asymmetric reactions of imines with homophthalic anhydride to form disubstituted 3,4-dihydroisoquinolones are reported. The use of N-mesyl aldimines is key, as more basic imines undergo rapid uncatalysed reactions, while imines possessing larger N-sulphonyl substituents form lactams with lower ee.Entities:
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Year: 2016 PMID： 27381361 DOI： 10.1039/c6ob00048g
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876